유방암종의 바늘 생검 조직에 대한 동결절편 검사의 유용성
Usefulness of Frozen Section Examination of Core Needle Biopsy in the Breast Carcinoma
김의정, 전이경, 홍성란, 김희숙, 강성수, 이지현, 이성공, 김혜선,
소속 상세정보
김의정 ( Kim Yee-Jeong )
성균관대학교 의과대학 삼성제일병원 병리과
전이경 ( Chun Yi-Kyeong )
성균관대학교 의과대학 삼성제일병원 병리과
홍성란 ( Hong Sung-Ran )
성균관대학교 의과대학 삼성제일병원 병리과
김희숙 ( Kim Hy-Sook )
성균관대학교 의과대학 삼성제일병원 병리과
강성수 ( Kang Sung-Soo )
성균관대학교 의과대학 삼성제일병원 외과
이지현 ( Lee Jee-Hyun )
성균관대학교 의과대학 삼성제일병원 외과
이성공 ( Lee Sung-Kong )
성균관대학교 의과대학 삼성제일병원 외과
김혜선 ( Kim Hye-Sun )
성균관대학교 의과대학 삼성제일병원 병리과
KMID : 0357920020360030163
Abstract
Background: Core needle biopsy (CNB) is widely used as the initial sampling method for breast cancer. And because frozen section (FS) diagnosis is rapid and reliable, we studied the diagnostic agreement between the diagnosis of FS of CNB and final diagnosis after surgery to evaluate the diagnostic accuracy of the FS of CNB.
Methods: Of 409 patients who were preoperatively diagnosed by FS of CNB and who underwent final surgery from 1996 through 2000, 24 cases were found to be ductal carcinoma in situ (DCIS) and 385 cases invasive carcinoma (IC). The diagnoses of FS of CNB were compared with final diagnoses.
Results: The diagnostic accuracy of carcinoma is 63.6% for DCIS and 86.9% for invasive carcinoma. Five cases (1.2%) could not be diagnosed because of material insufficiency for diagnosis. Twenty two cases (5.4%) were diagnosed as benign on FS, among which 20 (90.9%) were misdiagnosed by sampling error. Twenty seven cases (6.7%) were deferred on FS, 4 of these cases were DCIS, 5 were invasive lobular carcinoma (ILC), the rest displayed low nuclear grades or marked freezing artifacts.
Conclusion: The diagnostic accuracy of FS of CNB is very high except for cases of ILC and low grade DCIS. Considering the advantage of rapid evaluation, more definitive diagnosis, familiarity by pathologists and availability of ancillary study, FS of CNB is very useful method as the preoperative evaluation.
키워드
Mammary Neoplasms-Biopsy;Needle Frozen Sections
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