간내담석증 및 병발된 담관암종으로 절제된 간 조직내 주담관 상피의 증식세포핵항원 발현
Expression of Proliferating Cell Nuclear Antigen (PCNA) of Major Intrahepatic Bile Duct Epithelium in Resected Liver Tissue with Hepatolithiasis and Hepatolithiasis Associated with Cholangiocarcinoma
이시내, 성순희, 한운섭,
소속 상세정보
이시내 ( Lee Shi-Nae )
이화여자대학교 의과대학 병리학교실
성순희 ( Sung Sun-Hee )
이화여자대학교 의과대학 병리학교실
한운섭 ( Han Woon-Sup )
이화여자대학교 의과대학 병리학교실
KMID : 0357920020360040232
Abstract
Background: Histologic progressive changes of bile duct epithelium with hyperplasia, dysplasia and cholangiocarcinoma could be caused by hepatolithiasis. To be clarified as a neoplastic process, this histologic process should be evaluated with various aspects of cell biology.
Methods: Immunohistochemical study of proliferating cell nuclear antigen (PCNA) was performed on 45 cases (10; normal, 15; hyperplasia, 14; low-grade dysplasia:LGD, 6; high-grade dysplasia: HGD) of hepatolithiasis and 10 cases (all HGD) of hepatolithiasis with cholangiocarcinoma.
Results: In the hepatolithiasis, mean PCNA labelling indices (LI) of normal, hyperplasia, LGD and HGD of major intrahepatic bile duct epithelium were 24.5+/-4.3, 51.5+/-0.1, 62.0+/-.4 and 84.7+/-.3, respectively and gradually increased. Mean LI of PCNA in HGD of major intrahepatic bile duct epithelium of hepatolithiasis with cholangiocarcinoma was 68.7+/-.7, which was similar to that of LGD in hepatolithiasis without cholangiocarcinoma.
Conclusion:> Histologic transformation through hyperplasia, dysplasia and carcinoma in major intrahepatic bile duct epithelium of hepatolithiasis may be a neoplastic process if these histologic changes are evaluated in the cellular proliferation aspect.
키워드
Proliferating Cell Nuclear Anrigen;Bile Duct Diseases;Cholangiocarcinoma
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