잘룩창자곧창자 샘암종에서 p21 단백, p53 단백, Ki-67 단백의 발현 및 세포자멸사
Expression of p21, p53 and Ki-67, and Apoptosis in Colorectal Adenocarcinoma
박영의, 최경찬, 손진희, 최영희, 신형식,
소속 상세정보
박영의 ( Park Young-Euy )
한림대학교 의과대학 병리학교실
최경찬 ( Choi Kyung-Chan )
한림대학교 의과대학 병리학교실
손진희 ( Sohn Jin-Hee )
성균관대학교 의과대학 강북삼성병원 병리과학교실
최영희 ( Choi Young-Hee )
한림대학교 의과대학 병리학교실
신형식 ( Shin Hyung-Sik )
한림대학교 의과대학 병리학교실
KMID : 0357920020360050296
Abstract
Background: The purpose of this study is to assess the roles of p21 protein, p53 protein, and Ki-67 expressions and apoptosis in colorectal tumorigenesis.
Methods: Fifty-seven colorectal cancers and 15 villotubular adenomas were investigated by immunohistochemical staining for p21 protein, p53 protein, Ki-67, and in situ labeling of apoptotic cells. Clinicopathologic values (tumor size, histologic grade, Dukes stage, and lymph node metastasis) were compared with the incidence of expressions of p21 protein and p53 protein, index of Ki-67 expression, and apoptosis.
Results: The incidence of p21 protein expression was decreased with lymph node metastasis (p<0.005), and that of p53 expression was increased with lymph node metastasis (p<0.005). There were no statistically significant correlations among the p21 protein or p53 protein expressions, tumor size, histologic grade and stage. The correlation between the Ki-67 labeling index and the clinicopathologic values was not statistically significant. The labeling index of apoptosis was increased with the Astler-Coller stage (p<0.05). Statistical analysis revealed a significant inverse correlation between the p21 protein and p53 protein expressions (p<0.05).
Conclusion: It is suggested that p21 protein, p53 protein and the apoptotic labeling index are useful variables for the prognostic assessment of colorectal adenocarcinoma. Down-regulation of p21 protein expression may be associated with poor prognosis. Also, the expressions of p21 protein and p53 protein may play an important role in the tumorigenesis and progression of the colorectal adenoma-carcinoma sequence.
키워드
Colorectal Neoplasms;Immunohistochemistry;Apoptosis
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