담낭 샘암종에서 Matrix Metalloproteinase (MMP)-2, MMP-9, Tissue Inhibitor of Metalloproteinase (TIMP)-1,TIMP-2의 발현
Expression of Matrix Metalloproteinase (MMP)-2, MMP-9, Tissue Inhibitor of Metalloproteinase (TIMP)-1 and TIMP-2 in Adenocarcinomas of The Gallbladder
배종엽, 최진섭, 정현철, 박찬일, 박영년,
소속 상세정보
배종엽 ( Bae Jong-Yup )
포천중문의과대학교 구미차병원 병리학교실
최진섭 ( Choi Jin-Sub )
연세대학교 의과대학 외과학교실
정현철 ( Chung Hyun-Cheol )
연세대학교 의과대학 암센터
박찬일 ( Park Chan-Il )
연세대학교 의과대학 병리학교실
박영년 ( Park Young-Nyun )
연세대학교 의과대학 병리학교실
KMID : 0357920030370010001
Abstract
Background: Matrix metalloproteinase (MMP)-2 and MMP-9 degrade type IV collagen and are antagonized by the tissue inhibitors of metalloproteinase (TIMP)-2 and TIMP-1, respectively.
Methods: We studied by immunohistochemistry the expressions of MMP-2, MMP-9, TIMP-1 and TIMP-2 in 72 cases of adenocarcinoma of the gallbladder.
Results: The MMP-2, MMP-9 and TIMP-1 expressions were significantly higher in well/moderately differentiated adenocarcinomas than in poorly differentiated adenocarcinomas, in adenocarcinomas that had invaded the lamina propria/proper muscle than in those that had invaded the perimuscular connective tissue or beyond the serosa, and in adenocarcinomas with fungating growth than in those with infiltrative growth. The TIMP-2 expression showed a similar pattern without statistical significance. Regarding the status of lymph node metastasis, the MMP-2 expression was significantly higher in cases without lymph node metastasis. The MMP-2 and MMP-9 expressions were significantly related to those of TIMP-2 and TIMP-1, respectively, with regard to depth of invasion, differentiation, and growth patterns of the adenocarcinomas.
Conclusion: MMP-2, MMP-9, TIMP-1 and TIMP-2 are suggested to play important roles in the progression to early invasion of adenocarcinomas, in which the function of MMP-2 is inhibited by TIMP-2.
키워드
Gallbladder Neoplasms;Matrix Metalloproteinases;Tissue Inhibitor of Metalloproteinases;Immunohistochemistry
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