자궁목의 병기 I과 II 편평세포암종에서 Hypoxia-inducible Factor-1alpha 단백의 발현 : p53 단백 및 VEGF 발현과의 관련성
Expression of Hypoxia-inducible Factor-1alpha Protein in Stages I and II Squomous Cell Carcinomas of the Uterine Cervix : Relationship with p53 Protein and VEGF Expressions
서동수, 이창훈, 서강석, 윤만수,
소속 상세정보
서동수 ( Suh Dong-Soo )
부산대학교 의과대학 산부인과학교실
이창훈 ( Lee Chang-Hun )
부산대학교 의과대학 병리학교실
서강석 ( Suh Kang-Suek )
부산대학교 의과대학 병리학교실
윤만수 ( Yoon Man-Soo )
부산대학교 의과대학 산부인과학교실
KMID : 0357920030370020079
Abstract
Background: Under hypoxia, hypoxia-inducible factor-1alpha (HIF-1alpha) is known to activate the expression of various genes, including angiogenesis-related genes. The aim of this study was to evaluate the expression of HIF-1alpha protein and its relationship with p53 protein expression and angiogenesis in the squamous cell carcinoma (SCC) of the uterine cervix.
Methods: Using immunohistochemical methods, the expression of HIF-1alpha protein, p53 protein, vascular endothelial growth factor (VEGF), and microvessel count were evaluated in seventy cases of FIGO stages I and II SCC; and their results were compared with age, stage, and pelvic lymph node metastasis.
Results: Positive nuclear staining for HIF-1alpha protein was noted in 19 cases (27.1%). Carcinoma in situ or dysplastic lesions also revealed positive nuclear reaction along the lower part of the epithelium. The expression of HIF-1alpha protein was significantly related with those of p53 protein and VEGF (p < 0.05), but not with other clinicopathologic parameters. The microvessel count showed a significant difference regarding stage and VEGF expression (p < 0.05).
Conclusion: These findings suggest that HIF-1alpha expression in SCCs of the uterine cervix might be the early event of carcinogenesis and could be associated with p53 protein and VEGF expression. However, the prognostic significance of HIF-1alpha expression in stages I and II SCCs is undetermined.
키워드
Cervix Neoplasms;Carcinoma;Squamous Cell;Angiogenesis Factor;Immunohistochemistry
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