하부 호흡기의 침샘형암종과 폐 샘암종에서 Thyroid Transcription Factor-1의 발현
Expression of the Thyroid Transcription Factor-1 in Carcinomas of Salivary Gland Type and Pulmonary Adenocarcinomas
최종순, 서정욱, 서진원, 한정호,
소속 상세정보
최종순 ( Choi Jong-Sun )
성균관대학교 의과대학 삼성서울병원 병리학교실
서정욱 ( Seo Jeong-Wook )
서울대학교 의과대학 병리학교실
서진원 ( Seo Jin-Won )
성균관대학교 의과대학 삼성서울병원 병리학교실
한정호 ( Han Joung-Ho )
성균관대학교 의과대학 삼성서울병원 병리학교실
KMID : 0357920030370030180
Abstract
Background: Carcinomas of salivary gland type (CSGT) in the low respiratory tract are rare and often difficult to differentiate from pulmonary adenocarcinomas, which are more common and more aggressive than CSGT, especially in the biopsy specimens. Thyroid transcription factor-1 (TTF-1) is a tissue-specific transcription factor expressed in the thyroid gland and the lung. The purpose of this study is to elucidate the diagnostic utility of TTF-1 in discerning CSGT from adenocarcinomas in the low respiratory tract.
Methods: Immunohistochemical expression of TTF-1 was investigated in 14 CSGT (9 mucoepidermoid carcinomas and 5 adenoid cystic carcinomas) and 19 adenocarcinomas (5 well differentiated, 12 moderately differentiated and 2 poorly differentiated).
Results: Normal alveolar cells as well as bronchial epithelial cells showed the immunoreactivity for TTF-1, but not in the bronchial glands. In tumors, immunoreactivity for TTF-1 was identified in 17 out of 19 cases of adenocarcinomas (89%), but in none of 14 cases of CSGT. In adenocarcinomas, the immunoreactivity for TTF-1 was strongly correlated with the degree of differentiation (p<0.001).
Conclusion: These results suggest that TTF-1 can be a valuable marker in distinguishing CSGT from adenocarcinomas of the low respiratory tract.
키워드
Thyroid Transcription Factor-1;Carcinomas of Salivary;Gand Type;Mucoepidermoid Carcinoma;Adenoid Cystic Carcinoma;Adenocarcinoma
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