간내 담관암종에서의 p53, Rb, bcl-2 단백 발현과 Ki-67 표지지수와의 상관관계
Expression of p53, Rb, bcl-2 Proteins and Ki-67 Labeling Index in Intrahepatic Cholangiocarcinoma
구미진, 김홍진, 최준혁, 윤성수,
소속 상세정보
구미진 ( Gu Mi-Jin )
성삼병원 해부병리과
김홍진 ( Kim Hong-Jin )
영남대학교 의과대학 외과학교실
최준혁 ( Choi Joon-Hyuk )
영남대학교 의과대학 병리학교실
윤성수 ( Yun Sung-Soo )
영남대학교 의과대학 외과학교실
KMID : 0357920030370030186
Abstract
Background: The development and progression of a tumor can be determined by a complex multistep process involving the activation of oncogenes and the inactivation of tumor suppressor genes. The purpose of this study is to investigate the expression of p53, Rb, bcl-2 protein and Ki-67 labeling index in the intrahepatic cholangiocarcinoma.
Methods: We analyzed 36 cases of intrahepatic cholangiocarcinoma obtained by surgical resection. Expression of p53, Rb, bcl-2 proteins and Ki-67 labeling index were evaluated by immunohistochemical study.
Results: Expression of p53 protein was detected in 61.1% (22/36) of cholangiocarcinoma. Rb protein loss and overexpression were observed 27.8% (7/36) and 72.2% (29/36) of cholangiocarcinoma. But bcl-2 protein was not expressed. No significant correlation was found between p53, Rb and bcl-2 protein expression and age, sex, gross type, histologic grade, vascular invasion and lymph node metastases. The Ki-67 labeling index was significantly higher in p53 positive group and Rb overexpression group than in p53 negative group (p<0.01) and Rb loss group (p<0.05). There was a positive correlation between p53 protein and Rb protein expressions, but a negative correlation between Rb protein and bcl-2 protein expressions.
Conclusion: The overexpression of p53 protein and Rb protein may be closely associated with cholangiocarcinogenesis, while bcl-2 has a less crucial role in cholangiocarcinogenesis.
키워드
Liver neoplasms;Cholangiocarcinoma;p53 protein;Rb protein;bcl-2 protein;Ki-67
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