부비동비강미분화암종 -1예 보고-
Sinonasal Undifferentiated Carcinoma - A Case Report -
김활웅, 고경혁, 김철우,
소속 상세정보
김활웅 ( Kim Hwal-Woong )
경상대학교 의과대학 병리학교실
고경혁 ( Ko Gyung-Hyuck )
경상대학교 의과대학 병리학교실
김철우 ( Kim Chul-Woo )
서울대학교 의과대학 병리학교실
KMID : 0357920030370030214
Abstract
Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive neoplasm arising in the nasal cavity and paranasal sinuses. We report a case of SNUC in an old woman. The tumor was located at the nasal cavity and ethmoid sinus, extending to the cranial cavity. The nasopharynx was free from the tumor. Microscopically, the tumor formed nests or sheets containing medium-sized cells with small amounts of eosinophilic cytoplasm. High mitotic rates and tumor necrosis were characteristic. There was no evidence of glandular or squamous differentiation. The tumor was focally weak positive for cytokeratin, but negative for vimentin, leukocyte common antigen, S-100 protein, chromogranin, synaptophysin and neuron specific enolase. Epstein Barr Virus EBER-1 was not detected by in situ hybridization. SNUC is a highly aggressive tumor and must be distinguished from less aggressive sinonasal neoplasms.
키워드
Sinonasal Undifferentiated Carcinoma;Nasal Cavity;Paranasal Sinus;Keratin
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