한국에서의 췌장 점액낭종양과 관내유두점액종양의 유병률과
Prevalence and Clinicopathologic Features of Mucinous Cystic Tumor and Intraductal Papillary Mucinous Tumor of Pancreas in Korea
손진희, 김경미, 채승완, 김우호, 문우성, 박영년, 박철근, 유은실, 장희경, 정종재, 정진숙, 진소영, 최종상, 강대영,
소속 상세정보
손진희 ( Sohn Jin-Hee )
대한병리학회 소화기병리학연구회
김경미 ( Kim Kyung-Me )
대한병리학회 소화기병리학연구회
채승완 ( Chae Seoung-Wan )
대한병리학회 소화기병리학연구회
김우호 ( Kim Woo-Ho )
대한병리학회 소화기병리학연구회
문우성 ( Moon Woo-Sung )
대한병리학회 소화기병리학연구회
박영년 ( Park Young-Nyun )
대한병리학회 소화기병리학연구회
박철근 ( Park Cheol-Keun )
대한병리학회 소화기병리학연구회
유은실 ( Yu Eun-Sil )
대한병리학회 소화기병리학연구회
장희경 ( Chang Hee-Kyung )
대한병리학회 소화기병리학연구회
정종재 ( Jung Jong-Jae )
대한병리학회 소화기병리학연구회
정진숙 ( Jeong Jin-Sook )
대한병리학회 소화기병리학연구회
진소영 ( Jin So-Young )
대한병리학회 소화기병리학연구회
최종상 ( Choi Jong-Sang )
대한병리학회 소화기병리학연구회
강대영 ( Kang Dae-Young )
대한병리학회 소화기병리학연구회
KMID : 0357920030370040270
Abstract
Background: Mucin producing cystic neoplasms, such as mucinous cystic tumor(MCT) and intraductal papillary mucinous tumor(IPMT) of the pancreas, are uncommon but become increasing in their incidences. The pathologic classification and biologic potential of these neoplasms remain the subject of controversy.
Methods: The Gastrointestinal Pathology Study Group of the Korean Society of Pathologists analyzed the clinicopathologic characteristics of 85 cases of MCT and 72 cases of IPMT and examined the expression patterns of p53, CEA and MUC1.
Results: IPMT was located largely in the head, and showed connection with the main pancreatic duct (MPD, 68.1%), no ovarian-like stroma (0/72), and presence of intervening intratumoral normal or atrophic parenchyma. On the other hand, MCT was located largely in the tail(73%), and showed common ovarian-like stroma (66/80), rate connection with the MPD(7/85) and no intervening pancreatic parenchyma. CEA and p53 immunoexpressions were significantly increased from adenoma though borderline to carcinoma, but MUC 1 was expressed only in the invasive carcinoma among cases of MCT and IPMT.
Conclusions: The tumor location, ovarian-like stroma, connection with the MPD and intratumoral intervening nonneoplastic tissue were helpful in the differential diagnosis between IPMT and MCT. CEA and p53 expressions can be indicators of malignancy, while MUC 1 expression can indicate invasion.
키워드
Mucinous Cystic Tumor;Intraductal Papillary Mucinous Tumor;Pancreas
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