고등급 림프종으로 형질전환된 원발성 림프절 변연부 B-세포 림프종 - 1예 보고
High-grade Transformation of Primary Nodal Marginal Zone B-cell Lymphoma - A Case Report
김주헌, 강동욱, 박미자, 김진만,
소속 상세정보
김주헌 ( Kim Ju-Hun )
을지대학교 의과대학 병리학교실
강동욱 ( Kang Dong-Wook )
을지대학교 의과대학 병리학교실
박미자 ( Park Mee-Ja )
을지대학교 의과대학 병리학교실
김진만 ( Kim Jin-Man )
충남대학교 의과대학 병리학교실
KMID : 0357920030370040282
Abstract
Primary nodal marginal zone B-cell lymphoma (MZBCL) is recognized as a rare and distinct entity. The rate of histologic transformation into diffuse large B-cell lymphoma (DLBCL) seems lower than the rate of transformation in follicular lymphoma. We herein report a rare case of nodal MZBCL showing transformation into DLBCL. The patient was a 73-year-old female with cervical lymphadenopathy. On the initial biopsy, the lymph node architecture was diffusely effaced with an extensive interfollicular and parafollicular infiltrate of monocytoid B-cells. There were scattered large blastic B-cells without formations of compact sheets. The diagnosis of nodal MZBCL was made. The patient did not receive chemotherapy and was treated with a conservatively supportive regimen. Forty two months later, the patient developed a new cervical lymphadenopathy and a biopsy was performed. Histologically, the lymph node revealed diffuse sheets of transformed large B-cells showing prominent nucleoli. The diagnosis of DLBCL transformed from nodal MZBCL was made. The patient was treated with 3 cycles of combined CHOP chemotherapy and she showed clinical improvement. These observations suggest that an untreated primary nodal MZBCL may undergo high-grade transformation.
키워드
Lymphoma; B- Cell;Transformation;Lymphoma; Large-Cell;Diffuse
원문 및 링크아웃 정보
등재저널 정보