난소의 성숙낭성기형종에서 발생한 편평세포암종: 6증례의 p53 단백 및 p21WAF1/CIP1 발현과 임상 및 병리고찰
Squamous Cell Carcinoma Arising in Mature Cystic Teratoma of the Ovary: a Report of Six Cases and Immunohistochemistry of the p53 Protein and p21WAF1/CIP1
김경희, 서광선, 김동훈, 김성호, 김주헌, 강동욱, 박미자, 백종호,
소속 상세정보
김경희 ( Kim Kyung-Hee )
을지대학교 의과대학 병리학교실
서광선 ( Suh Kwang-Sun )
충남대학교 의과대학 병리학교실
김동훈 ( Kim Dong-Hoon )
을지대학교 의과대학 병리학교실
김성호 ( Kim Seong-Ho )
을지대학교 의과대학 병리학교실
김주헌 ( Kim Ju-Hun )
을지대학교 의과대학 병리학교실
강동욱 ( Kang Dong-Wook )
을지대학교 의과대학 병리학교실
박미자 ( Park Mee-Ja )
을지대학교 의과대학 병리학교실
백종호 ( Back Jong-Ho )
을지대학교 의과대학 병리학교실
KMID : 0357920030370050316
Abstract
Background: Mature cystic teratoma is a common type of ovarian tumor. Although squamous cell carcinoma (SCC) is the most common carcinoma in malignant transformations of ovarian mature cystic teratomas, SCC arising in a mature teratoma is rare.
Methods: This paper reports four cases of invasive SCC, a case of an adenosquamous cell carcinoma and a case of a pure in situ SCC arising in a mature cystic teratoma including a clinicopathological evaluation and an immunolistochemical study of the p53 protein and p21WAF1/CIP1.
Results: The mean age of the patients was 60 years. The size of the mature cystic teratomas in all cases were greater than 7.5cm in the largest diameter. Five cases showed the unclear accumulation of the p53 protein with no p21WAF1/CIP1 immunoreactivity. The other case showed the unclear accumulation of p21WAF1/CIP1 without p53 expression. There was a significant inverse relationship between the p53 protein level and p21WAF1/CIP1 expression.
Concluson: A clinicopathological evaluation showed that a SCC arising from a mature cystic teratoma must be included in a differential diagnosis when the patient is over 42years of age and the size of a mature cystic teratoma is greater than 75 mm in the largest diameter. It is suggested that p53 overexpression is implicated in the malignant transformations, and the p21WAF1/CIP1 expression level is dependent on alterations in the level of the p53 protein in these tumors.
키워드
Squamous cell carcinoma;Mature teratoma;p53;p21WAF1/CIP1
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