위암에서 CD44s와 CD44v6 발현과 임상병리학적 상과관계에 관한 연구
Studies of CD44s and CD44v6 Expressions and Correlation with Clinicopathologic Parameters in Gastric Carcinoma
이주호, 임정화, 전호종,
소속 상세정보
이주호 ( Li Zhu-Ho )
조선대학교 의과대학 병리학교실
임정화 ( Lin Zhen-Hua )
고려대학교 의과대학 병리학교실
전호종 ( Jeon Ho-Jong )
조선대학교 의과대학 병리학교실
KMID : 0357920030370050320
Abstract
Backgroud: The aim of this study is to elucidate the relationship between CD44s and CD44v6 expression level and the biological characteristics of a gastric carcinoma.
Methods: CD44s and CD44v6 expression was investigated in 56 gastric carcinomas, 18 dysplasias, and 22 normal mucosae by immunohischemical staining.
Results: The CD44s and CD44v6 expression rates in gastric carcinomas, dysplasi, and normal mucosae were 80.3% and 83.9%, 72.2% and 77.8% and 13.6% and 4.5%, respectively. Statistical analysis showed significant difference after comparing a gastric carcinomas and dysplasia to the normal mucosae (p<0.001). The CD44s and CD44v6 expression rate in the cases with invasion to the muscle proper and serosa were 60.7% and 57.1%, and 82.4% and 88.2%, respectively. Both showed a significant statistical difference compared to the expression rates in the cases with invasion to the mucosae and submucosae. The CD44s and CD44v6 expression rates in gastric carcinomas with a lymph node metastasis (p<0.001 and (p<0.01, respectively). CD44s and CD44v6 were also expressed in the normal vassal cells around gastric carcinomas.
Conclusions: The CD44s and CD44v6 expression showed a significant relationship with gastric cardinogenesis, toward an aggressive biological behavior.
키워드
Gastric Carcinoma;Dysplasia;CD44s;CD44v6
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