Hepatitis B virus X 형질전환 생쥐 간의 병리소견
Pathologic Findings in the Liver of Hepatitis B Virus X Transgenic Mice
문형배, 유대열, 소병준, 김학철, 한원철, 윤기중, 유형륜,
소속 상세정보
문형배 ( Moon Hyung-Bae )
원광대학교 의과대학 병리학교실
유대열 ( Yu Dae-Yeul )
생명공학연구소
소병준 ( So Byung-Jun )
원광대학교 의과대학 외과학교실
김학철 ( Kim Haak-Cheol )
원광대학교 의과대학 내과학교실
한원철 ( Han Won-Cheol )
원광대학교 의과대학 병리학교실
윤기중 ( Yun Ki-Jung )
원광대학교 의과대학 병리학교실
유형륜 ( Yoo Hyung-Nyoon )
원광대학교 의과대학 병리학교실
KMID : 0357920030370050342
Abstract
Background: The aim of this study was to investigate the hepatic pathology of HBx transgenic mice.
Methods: The gross and histological examinations were done in 125 HBx transgenic mice and 34 non-transgenic littermates.
Results: The incidence of a hepatic tumor was increased in the HBx transgenic mice older than 7 months and the overall incidence of a hepatic tumor was 62.2% (51/82) in the 13-18 months group of the HBx transgenic mice. The size of the hepatic tumor was 2.06±1.92 mm in the 7-12 months group and 4.94±5.05 mm in the 13-18 months group of HBx transgenic mice. All hepatic tumors were hepatocellular carcinomas and the histological patterns of hepatocellular carcinoma were either solid (84.2%, 48/57) or trabecular (15.8%, 9/57). Dysplastic changes in the hepatocytes were evident in 59.2% (74/125) of the HBx transgenic mice. There was lymphocyte infiltration, necrosis, fatty metamorphosis in both the dysplastic and tumor areas of the HBx transgenic mice. Vascular ectasia was identified in the tumor area of the HBx transgenic mice.
Conclusions: The pathological findings of the HBx transgenic mice were dysplastic changes in the hepatocytes and development of a hepatocellular carcinoma associated with lymphocyte infiltration, necrosis, fatty metamorphosis in the dysplastic area and tumor area of the HBx transgenic mice.
키워드
HBx-Mice;Transgenic;Carcinoma;Hepatocellular;Pathology
원문 및 링크아웃 정보
등재저널 정보