담낭암종에서 Urokinase-Type Plasmlnogen Activator와 Plasminogen Activator Inhibitor-1의 발현
Expression of Urokinase-type Plasminogen Activator (uPA) and Plasminogen Activator Inhibitor-1 (PAH) in Gallbladder Carcinoma
이기형, 박문향, 강행지, 이승연,
소속 상세정보
이기형 ( Lee Kee-Hyung )
한양대학교 의과대학 병리학교실
박문향 ( Park Moon-Hyang )
한양대학교 의과대학 병리학교실
강행지 ( Kang Haeng-Ji )
서울위생병원 병리과
이승연 ( Lee Seung-Yeoun )
세종대학교 자연과학대학 응용수학과
KMID : 0357920030370060384
Abstract
Background: There are evidences that uPA and its inhibitor play a key role in tumor spread. We studied whether uPA and PAI-1 expressions could serve as prognostic parameters along with clinical, gross and microscopic findings in gallbladder carcinomas.
Methods: We analyzed 42 cases of gallbladder careinomas by immunohistochemical staining and clinicopathologic parameters.
Resuits: uPA and PAI-1 were more frequently expressed in the adenocarcinoma than in the normal or benign gallbladder tissue. The uPA expression in the glands of low grade adenocarcinoma was significantly correlated with both distant and lymph node melastases. The uPA expression in the stroma around the low grade adenocarcinoma was significantly correlated with either distant or lymph node metastasis. The PAI-1 expression was significantly correlated with lymph node metastasis only for both distant and lymph node metastases. In multivariate analysis, the lymphatic invasion was significantly related to poor survival (p=0.0115). In univariate analysis, the cases without lymphatic invasion had prolonged survival. Positive expression of uPA in the glands of low-grade adenocarcinoma was significatly correlated with poor survival (p=0.0391).
Conclusion: In conjunction with clinicopathologic tindings, expressions of uPA and PAI-1 may be useful prognostic markers in gallbladder carcinomas.
키워드
Urokinase;Type Plasminogen Activator;Plasminogen Activator Inhibitor 1;Gallbladder Neoplasms;Prognosis
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