유방의 침윤성 관암종에서 p21, p53 및 bcl-2 단백의 발현
Expression of p21, p53 and bd-2 Proteins in Invasive Ductal Carcinoma of the Breast
조향정, 윤기중, 문형배,
소속 상세정보
조향정 ( Jo Hyang-Jeong )
원광대학교 군산의료원 병리과
윤기중 ( Yun Ki-Jung )
원광대학교 의과대학 병리학교실
문형배 ( Moon Hyung-Bae )
원광대학교 의과대학 병리학교실
KMID : 0357920030370060393
Abstract
Background: This study was designed to investigate the prognostic significance of p21, p53, and bcl-2 proteins in invasive ductal carcinoma of the breast.
Methods: Seventy-two cases of invasive ductal carcinoma were examined by immunohistochemical staining for p21, p53 and bcl-2 proteins. The results were correlated with clinicopathological variables, including age, tumor size, histologic grade, nuclear grade, lymph node status, estrogen receptor (ER) and progesterone receptor (PR) expression.
Results: Of 72 cases, p21, p53 and bcl-2 proteins were positive in 25(34.8%), 35(50.0%) and 27(37.5%), respectively. There were no statisticaly significant correlations between the p21 protein expression and the other clinicopathological variables. The expression of p53 protein, however, showed a significant relation to ER expression, and that of bcl-2 was positively correlated with tumor size. In survival analysis, p21, p53 and bcl-2 proteins, nuclear grade and lymph node stafus were associated with survival rate.
Conclusions: These results indicate that p21, p53, and bcl-2 proteins might play a role in tumorigenesis of breast carcinoma. In addition, the increased expression of p21, p53, and bcl-2 proteins could be used as factors suggesting poor prognosis in breast carcinomas.
키워드
p21;p53;bcl-2;Breast Neoplasms
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