유방암종에서 MMP-2, MT1-MMP, TIMP-2 mRNA의 발현
Expression of MMP-2, MT1-MMP, and TIMP-2 mRNA in Breast Carcinomas
김동원, 진소영, 이동화,
소속 상세정보
김동원 ( Kim Dong-Won )
순천향대학교병원 병리과
진소영 ( Jin So-Young )
순천향대학교병원 병리과
이동화 ( Lee Dong-Wha )
순천향대학교병원 병리과
KMID : 0357920030370060400
Abstract
Background: The activation of proMMP-2 is induced by membrane type 1-matrix metalloproteinase (MT1-MMP), but inhibited by tissue inhibitors of matrix metalloproteinase type 2 (TIMP-2). This study was carried out to establish the pattem of mRNA expression of MMP-2, MT1-MMP, and TIMP-2 in breast carcinomas.
Methods: Seventy-nine cases of invasive ductal carcinoma, 10 of ductal carcinoma in situ, and 10 of fibrocystic disease as a control were analysed for the expression of MMP-2, MT1-MMP, and TIMP-2 mRNA, using in situ hybridization. Correlations of the results with the clinical stage, tumor size, nodal status, and nuciear grade were analysed.
Resulits: The expression rates of MMP-2, MT1-MMP, and TIMP-2 mRNA in invasive ductal carcinoma were 68%, 73%, and 56%, respectively. They were localized to both stromal and tumor cells, but mainly in th latter. The MMP-2 mRNA expression was significantly correlated with the clincal stage (p＜0.05), while the expression of TIMP-2 mRNA was inversely correlated with clinical stage and tumor size(p＜0.05). Significant positive correlations between MMP-2 and MT1-MMP expressions, along with inverserelationships between MMP-2 and TIMP-2, and between TIMP-2 and MT1-MMP, were also found.
Conclusions: MMP-2 and TIMP-2 mRNA expressions might be useful as one of a range of prognostic prameters in breast carcinoma patients.
키워드
Breast Neoplasms;Gelatinase A;Tissue Inhibitor of Metalloproteinase 2;Membrane;type 1 Matrix Metalloproteinase;In Situ Hybridization
원문 및 링크아웃 정보
등재저널 정보