미만성 대세포 B 림프종에서 P53, BCL-2 단백 발현 및 세포증식지수와 국제예후지표와의 연관성 분석
Prognostic Significance of P53, BCL-2 and PCNA in Diffuse Large B-Cell Lymphoma
김동철, 이아원, 이교영, 강창석, 박경신, 심상인,
소속 상세정보
김동철 ( Kim Dong-Chul )
가톨릭대학교 의과대학 임상병리학교실
이아원 ( Lee Ah-Won )
가톨릭대학교 의과대학 임상병리학교실
이교영 ( Lee Kyo-Young )
가톨릭대학교 의과대학 임상병리학교실
강창석 ( Kang Chang-Suk )
가톨릭대학교 의과대학 임상병리학교실
박경신 ( Park Gyeong-Sin )
가톨릭대학교 의과대학 임상병리학교실
심상인 ( Shim Sang-In )
가톨릭대학교 의과대학 임상병리학교실
KMID : 0357920030370060407
Abstract
Background: Diffuse large B-cell lymphoma (DLBCL) represents a diverse spectrum of clinical presentation, morphologr, and genetic and molecular alterations, and shows variable prognoses and responses to therapy. The lnternational Prognosis Lndex (IPI)is widely used to predict prognosis but is not precise.
Methods: Thirty-nine cases of DLBCL were classifie into low-and high-risk groups according to IPI and were analyzed for their p53, BCL-2,BCL-6 and PCNA expression profile by immunohistochemical staining and overall survival rate.
Results: The mean age of the 39 patients, 23 males and 16 females, was 52.6 years. There were 23 cases (59.0%)in the low-risk group and 16(41.0%)in the high-risk group. p53, BCL-2, BCL-6 and PCNA expression was higher in the high-risk group than in the low-risk group, but only the differences in p53 and BCL-2 expression were statistically significant (p＜0.05).
Conclusion: The p53 and BCL-2 protein expression in DLBCL may supplement IPI in predicting the prognosis of DLBCL patients.
키워드
Lymphoma;Large Cell;Diffuse;p53;bcl-2;Proliferating Cell Nuclear Antigen
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