대장 종양에서 CD43의 발현에 관한 연구
Expression of CD43 in Colorectal Adenocarcinoma
정경천, 배영미, 안혜경, 김혜은, 장명철, 노혜린, 채기봉, 최원진, 김우진, 박원서,
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정경천 ( Jung Kyeong-Cheon )
한림대학교 의과대학 병리학교실
배영미 ( Bae Young-Mee )
강원대학교 의과대학 병리학교실
안혜경 ( Ahn Hye-Kyung )
한림대학교 의과대학 병리학교실
김혜은 ( Kim Hye-Eun )
강원대학교 의과대학 외과학교실
장명철 ( Jang Myung-Chul )
강원대학교 의과대학 외과학교실
노혜린 ( Roh Hye-Rin )
강원대학교 의과대학 외과학교실
채기봉 ( Chae Gi-Bong )
강원대학교 의과대학 외과학교실
최원진 ( Choi Won-Jin )
강원대학교 의과대학 외과학교실
김우진 ( Kim Woo-Jin )
강원대학교병원 임상의학연구소
박원서 ( Park Weon-Seo )
강원대학교병원 임상의학연구소
KMID : 0357920040380010008
Abstract
Background: CD43 is a sialoglycoprotein that is highly expressed on most leukocytes, except on B lymphocytes and dendritic cells. CD43 has been reported to be involved in the adhesion and apoptosis of lymphocytes. Although the aberrant expression of CD43 antigen in non-lymphoid tissues has been reported, the expression of the CD43 antigen in gastrointestinal malignancies is not well studied. Here, we studied the expression of CD43 in colon adenocarcinoma using the anti-CD43 monoclonal antibody developed in our laboratory.
Methods: Thirty patients who had undergone surgical resection for colorectal carcinoma were recruited. The expression of CD43 molecule was determined by analyzing the formalin-fixed, paraffin-embedded specimens immunohistochemically using our newly developed anti-CD43 mAb (K06). The results obtained by the immunohistochemical analysis correlated to the clinicopathological parameters.
Results: The expression of CD43 were found in 20 out of 30 colorectal carcinoma cases. The expression of CD43 antigen is higher in well differentiated adenocarcinomas than poorly or moderately differentiated adenocarcinomas.
Conclusions: The new anti- CD43 mAb might be helpful for the detection of the expression of CD43 on colorectal carcinoma cells. Further studies are required to assess the relationship between the CD43 expression and the colorectal carcinogenesis.
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