갑상샘 종양에서 p53, cyclin D1 및 c-myc 발현의 의의
Significance of p53, cyclin D1 and c-myc Expressions in Thyroid Tumors
이주호, 전호종, 이미자,
소속 상세정보
이주호 ( Li Zhu-Ho )
조선대학교 의과대학 병리학교실
전호종 ( Jeon Ho-Jong )
조선대학교 의과대학 병리학교실
이미자 ( Lee Mi-Ja )
조선대학교 의과대학 병리학교실
KMID : 0357920040380010029
Abstract
Background: The G1/S phase proteins of the cell cycle play critical roles in tumorigenesis and tumor progression. Our aim was to investigate the significance of p53, cyclin D1 and c-myc expressions in thyroid tumors.
Methods: The expressions of these proteins were examined in 217 cases of thyroid tumors and tissues using immunohistochemistry. The results were correlated with lymph node metastasis.
Results: p53 expression was seen in 75.5, 47.5, 66.7, and 50% of papillary carcinomas (PC), follicular carcinomas (FC), undifferentiated carcinomas (UC) and follicular adenomas (FA), respectively. There was a significant difference between these expressions in these tumors and the results in nodular hyperplasia (NH) and normal tissues. Cyclin D1 expression was noted in 80.0, 68.4, 66.7, 61.1 and 79.5% of PC, FC, UC, FA and NH, respectively. c-myc expression was seen in 80.0, 94.2, 66.7, 66.7 and 52.3% of PC, FC, UC, FA and NH, respectively. There was a significant association between the expressions in these tumors and the results in normal tissues. The expressions of p53, cyclin D1 and c-myc were not correlated with lymph node metastasis.
Conclusions: These findings suggest the expressions of p53, cyclin D1 and c-myc may act in the early stage, and participates in tumorigenesis and promoting cell growth.
키워드
원문 및 링크아웃 정보
등재저널 정보