Osteofibrous Dysplasia-Like Adamantinoma - A Case Report with its Immunohistochemical and Ultrastructural Studies -
김나래, 안긍환, 김근우, 조현이, 오하영, 정동해,
소속 상세정보
김나래 ( Kim Na-Rae )
가천의대 길병원 병리과
안긍환 ( Ahn Geung-Hwan )
성균관대학교 의과대학 삼성서울병원 병리과
김근우 ( Kim Keun-Woo )
강원대학교 의과대학 정형외과학교실
조현이 ( Cho Hyun-Yee )
가천의과학대학교 길병원 병리과학교실
오하영 ( Oh Ha-Young )
한양대학교 구리병원 병리과
정동해 ( Chung Dong-Hae )
가천의과학대학교 길병원 병리과학교실
KMID : 0357920040380010050
Abstract
Osteofibrous dysplasia (OFD)-like adamantinoma is a rare skeletal tumor that is characterized by the predominant OFD-like pattern with scattered epithelial nests. Adamantinoma shares clinical features (the majority of lesions in the tibia and the prevalent age group), radiologic findings (radiolucency with sclerotic shadow), and pathologic similarities (particularly the presence of scattered cytokeratin-positive stromal cells) with OFD. We describe a case of OFD-like adamantinoma. Epithelial cell nests express the epithelial membrane antigen, pancytokeratin, CK14, and collagen type IV. Ultrastructurally, the oval to spindle cells in the epithelial foci had abundant tonofilaments, and well-formed desmosomes with dense plaques, of which well preserved desmosomes are demonstrated for the first time in OFD-like adamantinoma. These immunohistochemical and ultrastructural findings further support that the origin of epithelial cells of classic and OFD-like adamantinoma are epithelial cells transformed from fibroblastic cells in the proliferating osteofibrous tissue.
키워드
Adamantinoma;Ossifying Fibroma;Microscopy;Electron;Immunohistochemistry
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