Odontogenic Gingival Epithelial Hamartoma; with Reference to the Expression of Ameloblastin Gene by in situ Hybridization and Immunohistochemistry
김나래, 서연림, 지제근, 이영준, 이석근, 이재일, 임창윤, 박지영,
소속 상세정보
김나래 ( Kim Na-Rae )
가천의대 길병원 병리과
서연림 ( Suh Yeon-Lim )
성균관대학교 의과대학 삼성서울병원 병리학교실
지제근 ( Chi Je-Geun )
인제대학교 의과대학 일산백병원 병리과
이영준 ( Lee Young-Joon )
강릉대학교 치과대학 구강병리학교실
이석근 ( Lee Suk-Keun )
강릉대학교 치과대학 구강병리학교실
이재일 ( Lee Jae-Il )
서울대학교 치과대학 구강병리학교실
임창윤 ( Lim Chang-Yun )
서울대학교 치과대학 구강병리학교실
박지영 ( Park Ji-Young )
가천의대 길병원 약리학과
KMID : 0357920040380020116
Abstract
Odontogenic gingival epithelial hamartoma (OGEH) is an extremely rare lesion characterized by an abnormal proliferation of odontogenic epithelium. This lesion is thought to arise from the rest of the dental lamina lying dormant in the gingival tissue after odontogenesis. Distinguishing OGEH from the granular cell variant of ameloblastoma and central odontogenic fibroma is important. To date, only eleven cases have been reported, and its pathogenesis remains unclear. We report here on a case of OGEH, where the epithelial strands in the lesion were conspicuously positive for the antisera of cytokeratin 19 and ameloblastin. Tumor cells intensely expressed ameloblastin mRNA by in situ hybridization. To the best of our knowledge, this is the first case of OGEH to which ameloblastin immunohistochemical stain and in situ hybridization were applied. Although our study is limited to a single case, the coexpression of cytokeratin 19 and ameloblastin might indicate the origin and specific cytodifferentiation of OGEH is quite different and unique, when contrasted to other odontogenic tumors.
키워드
Odontogenic Gingival Epithelial Hamartoma;Ameloblastin;Cytokeratin 19
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