Minimal Deviation Adenocarcinoma, Mucinous Type, of the Uterine Cervix- Report of a Case with Extensive Metastasis to the Uterine Corpus and Bilateral Adnexae -
장은덕, 이은정, 김경미, 신옥란, 구영미, 안희정, 강창석,
소속 상세정보
장은덕 ( Chang Eun-Deok )
가톨릭대학교 의과대학 임상병리학교실
이은정 ( Lee Eun-Jung )
가톨릭대학교 의과대학 임상병리학교실
김경미 ( Kim Kyoung-Mee )
가톨릭대학교 의과대학 임상병리학교실
신옥란 ( Shin Ok-Ran )
가톨릭대학교 의과대학 임상병리학교실
구영미 ( Ku Young-Mi )
가톨릭대학교 의과대학 영상의학교실
안희정 ( Ahn Hee-Jung )
포천중문의과대학교 분당차병원 병리학교실
강창석 ( Kang Chang-Suk )
가톨릭대학교 의과대학 임상병리학교실
KMID : 0357920040380020121
Abstract
Minimal deviation adenocarcinoma is an extremely well differentiated variant of cervical adenocarcinoma, and is frequently misdiagnosed due to its benign-looking histopathological features. A 38-year-old woman was diagnosed as having had a minimal deviation adenocarcinoma in the cervix, metastasizing to the uterine body and bilateral adnexae. She had a history of right salpingo-oophorectomy 3 years ago, and was diagnosed as having a mucinous cystadenoma. Histologically, the tumor cells were so well-differentiated that they appeared to be almost the same as those of the non-neoplastic cervical glands. Similar glands were found in both ovaries and in the left fallopian tube. PAS staining showed a negative or apical positive pattern in the endocervical-like glands. Immunohistochemical studies for CEA, ER/PR, cytokeratin 20, and p53 were negative, but positive for cytokeratin 7. The HPV DNA microarray test was negative. Clinically, this proved to be an advanced, biologically aggressive disease.
키워드
Adenocarcinoma;Mucinous;Cervix
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