정상 및 선천성 기형 심장에서 양쪽 심방의 형태학적 차이 및 위치 결정에 관한 연구
Morphologic Difference of the Atrial Chambers and Determination of the Atrial Situs in the Normal and Congenitally Malformed Heart
김어진, 서정욱,
소속 상세정보
김어진 ( Kim Eo-Jin )
성균관대학교 의과대학 강북삼성병원 병리과학교실
서정욱 ( Seo Jeong-Wook )
서울대학교 의과대학 병리학교실
KMID : 0357920040380030174
Abstract
Background: Identification of atrial situs is the initial step in any segmental analysis and classification of congenital heart malformations. To elucidate the differences for both atria of the normal and congenitally malformed heart, we performed morphological studies on the human heart with or without abnormal laterality syndrome.
Methods: Five normally formed human hearts, five hearts with right isomerism and five hearts with left isomerism were used in this study. The postero-superior walls of the atrial chambers were examined.
Results: Although the division line of the ventral and dorsal compartments was not as conspicuous as was seen in the right atrium of rat embryo previously studied, this division line existed as a well-developed terminal crest and vestigial structure of the antero-lateral extension of the terminal crest. These structures were noted in the right atrial chambers of normal human hearts and in the bilateral atrial chambers of right isomerism. However, they were totally absent in the bilateral atrial chambers in hearts with left isomerism.
Conclusions: Our study showed that the right atrial chamber in the normally developed human heart has vestigial components of division between the ventral and dorsal compartment, and hearts with right isomerism and left isomerism have differential development of the ventral and the dorsal compartment.
키워드
Morphogenesis;Heart Atrium;Congenital Heart Defect;lsomerism
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