위 샘암종에서 cyclin E, p53, E-cadherin 및 β-catenin 발현의 의의
Significance of Cyclin E, p53, E-cadherin, and β-Catenin Expressions in Gastric Adenocarcinomas
현용배, 이미자, 서재홍,
소속 상세정보
현용배 ( Xuan Long-Pei )
조선대학교 의과대학 병리학교실
이미자 ( Lee Mi-Ja )
조선대학교 의과대학 병리학교실
서재홍 ( Suh Chae-Hong )
조선대학교 의과대학 병리학교실
KMID : 0357920040380040213
Abstract
Background: Gastric cancer is reported to be one of the leading causes of mortality in Korea. Our aim was to evaluate the clinicopathologic usefulness of cyclin E, p53, E-cadherin and β-catenin expressions in gastric adenocarcinomas.
Methods: Immunohistochemical staining was performed on the 40 early gastric carcinoma (EGC) cases and 69 advanced gastric carcinoma (AGC) cases to examine the relationship with the clinicopathologic parameters.
Results: Cyclin E and p53 expressions were significantly lower in the mucosal or submucosal invasion group compared with those in the muscle invasion and subserosal or serosal invasion groups. Cyclin E expression was significantly higher in the node-positive group compared with that in the node-negative group. The loss of β-catenin expression was significantly higher in the node-negative group. p53 expression was significantly higher in the intestinal type group than that in the diffuse type group. Loss of E-cadherin expression was significantly higher in the diffuse type group. Cyclin E expression correlates with p53 expression.
Conclusions: The depth of invasion seems to correlate with cyclin E and p53 expressions. Lymph node metastasis may correlate with loss of β-catenin expression.
키워드
Gastric cancer;Cyclin E;E-cadherin;β-catenin;p53
원문 및 링크아웃 정보
등재저널 정보