자궁목 병변에서 p16, p53 단백과 Ki-67의 발현
Studies on the Expression of the p16 (INK4A), p53, and Ki-67 Labeling Index in Inflammatory and Neoplastic Diseases of the Uterine Cervix
이종실, 이정희, 고경혁, 신정규, 김활웅,
소속 상세정보
이종실 ( Lee Jong-Sil )
경상대학교 의과대학 병리학교실
이정희 ( Lee Jeong-Hee )
경상대학교 의과대학 병리학교실
고경혁 ( Ko Gyung-Hyuck )
경상대학교 의과대학 병리학교실
신정규 ( Shin Jeong-Kyu )
경상대학교 의과대학 산부인과학교실
김활웅 ( Kim Hwal-Woong )
경상대학교 의과대학 병리학교실
KMID : 0357920040380040238
Abstract
Background: Prior studies of p16, p53, and Ki-67 expression have suggested that these markers may be preferentially expressed in cervical neoplasms. The purpose of this study was to assess the expression and clinical significance of p16, p53 proteins, and the Ki-67 labeling index in the cervical lesions.
Methods: We analyzed 54 uterine cervical specimens obtained by surgical biopsy. The expression of p16, p53 proteins, and Ki-67 was evaluated by immunohistochemical methods. The immunohistochemical findings were then correlated with the histologic diagnosis.
Results: Positive scores for p16, p53, and Ki-67 were seen in 75% (6/8), 0% (0/8), and 13% (1/8) of low grade intraepithelial lesions (LSIL), respectively, and 100% (23/23), 17% (4/23), and 74% (17/23) of high grade intraepithelial lesions (HSIL), respectively, and 100% (10/10), 20% (2/10), and 70% (7/10) of invasive squamous cell carcinomas, respectively. Both normal epithelium and inflammatory lesions scored negative for these three markers in all of the 13 cases. p16 and Ki-67 expression correlated with the severity of uterine cervix lesions.
Conclusions: p16 and Ki-67 are complementary surrogate biomarkers for cervical squamous intraepithelial neoplasia. However, immunohistochemical expression for p53 has no correlation with the grade of cervical squamous intraepithelial neoplasia.
키워드
Cervical Neoplasms;p16;p53;ki-67;Immunohistochemistry
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