아급성 림프절염의 임상ㆍ병리학적 분석
The Clinicopathologic Analysis of Kikuchi´s Lymphadenitis
최정우, 김인선, 채양석, 이주한, 이지혜,
소속 상세정보
최정우 ( Choi Jung-Woo )
고려대학교 의과대학 병리학교실
김인선 ( Kim In-Sun )
고려대학교 의과대학 병리학교실
채양석 ( Chae Yang-Seok )
고려대학교 의과대학 병리학교실
이주한 ( Lee Ju-Han )
고려대학교 의과대학 병리학교실
이지혜 ( Lee Ji-Hye )
고려대학교 의과대학 병리학교실
KMID : 0357920040380050289
Abstract
Background: Kikuchi´s disease has been known as a self-limiting lymphadenitis mostly affecting the cervical lymph nodes of young women.
Methods: We retrospectively reviewed the clinical data of 77 cases of Kikuchi´s lymphadenitis from 1996 to 2003 at Korea University Medical Center.
Results: Histologically, 69 available cases were classified into three types: proliferative (60.8%), necrotizing (33.3%), and xanthomatous type (5.7%). These three types differed in terms of their clinical features, showing tenderness most predominantly in the necrotizing type. In spite of the insufficient numbers of cases, the data on the duration of the disease well correlated with the possible progression of the three histologic types (Kikuch´s disease begins as proliferative type, then progress into necrotizing type and finally resolves into xanthomatous type). During the ten-month period of the mean follow-up, the recurrence rate was 7.0%. Three and two patients developed into pulmonary tuberculosis and systemic lupus erythematosus, respectively, but there were no prognostic differences among the three types.
Conclusions: Our results confirmed that Kikuchi´s lymphadenitis is a self-limiting necrotizing lymphadenitis with a low rate of recurrence. Here, we suggest that the classification of histologic types have some meanings because of their differences in certain clinical aspects and possible sequential disease progression.
키워드
Kikuchi´s disease;Lymph Nodes;Recurrence
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