Comparative Analysis of Serum Mannose-Binding Lectin in Normal Population and Patients with Different Types of Cancer
김범준, 이응석, 김영식, 원남희, 염범우, 한은미, 이대일, 안긍환,
소속 상세정보
김범준 ( Kim Bum-Joon )
고려대학교 의과대학 병리학교실
이응석 ( Lee Eung-Seok )
고려대학교 의과대학 병리학교실
김영식 ( Kim Young-Sik )
고려대학교 의과대학 병리학교실
원남희 ( Won Nam-Hee )
고려대학교 의과대학 병리학교실
염범우 ( Yeom Bom-Woo )
고려대학교 의과대학 병리학교실
한은미 ( Han Eun-Mee )
고려대학교 의과대학 병리학교실
이대일 ( Lee Da-Le )
고려대학교 의과대학 병리학교실
안긍환 ( Ahn Geung-Hwan )
삼성서울병원 병리과
KMID : 0357920040380050306
Abstract
Background: Mannose-binding lectin (MBL) is a serum protein of innate immunity. Its genetic mutations lead to deficiency of serum MBL and recurrent pyogenic infection in childhood. However, little is known about the frequency of its gene mutations or serum levels in Korean population and patients with cancers.
Methods: We studied the mutational genotypes of MBL exon 1 codon 52, 54, and 57 or serum MBL levels from 102 normal adults and 228 cases of breast, stomach, colon, uterine cervical, and lung cancers by allele-specific PCR and enzyme-linked immunosorbent assay.
Results: MBL gene mutations were found in 32 of 102 normal adults (31.4%), and were restricted only to exon 1 codon 54 showing homozygous (n=5, 4.9%) or heterozygous mutations (n=27, 26.5%). Mean and median serum MBL in the patients with cancers were increased (2,647 1,742 and 2,915 ng/mL, mean S.D. and median) than those of normal adults (1,906 1,359 and 1,758 ng/mL). Serum MBL level was significantly increased in the patients with stomach, uterine cervical, colon, and lung cancers.
Conclusion: Our results indicate that the frequency and pattern of MBL gene mutations and its serum level is very similar among northeastern Asian populations. In addition, MBL might be involved in an immunologic response against common cancers, although further studies are needed.
키워드
Mannose;binding lectin;Mutation;Cancer
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