파제트병과 동반된 유방암에서 Anaphase Promoting Complex (APC)와 APC조절 단백의 발현
Expression of Anaphase Promoting Complex (APC) and APC Regulatory Proteins in Invasive Ductal Carcinoma Associated with Paget´s Disease
박광하, 양우익, 강엽, 이상엽, 이광길,
소속 상세정보
박광하 ( Park Kwang-Hwa )
연세대학교 원주의과대학 병리학교실
양우익 ( Yang Woo-Ick )
연세대학교 의과대학 병리학교실
강엽 ( Kang Yup )
아주대학교 의과학연구소
이상엽 ( Yi Sang-Yeop )
관동대학교 의과대학 병리학교실
이광길 ( Lee Kwang-Gil )
연세대학교 원주의과대학 병리학교실
KMID : 0357920040380050319
Abstract
Background: Oncogene expression in Paget´s disease of the breast is not well known. To characterize invasive ductal carcinoma associated with Paget´s disease, we studied expression of anaphase promoting complex (APC) with its regulatory proteins.
Methods: Immunohistochemical stainings were done with 10 cases of invasive ductal carcinoma associated with Paget´s disease for APC, pituitary tumor transforming gene (PTTG), cyclin B1, p53, cyclin D1, and c-erbB-2. The expressions of these markers in Paget´s disease were compared with those in the associated with carcinoma.
results: APC, PTTG, cyclin B1, and c-erbB-2 were positive in all of the cases with both Paget´s disease and underlying carcinoma. p53 was expressed in Paget´s disease of 6 cases (60%) and in carcinoma of 7 cases (70%). Cyclin D1 was positive in Paget´s disease of 8 cases (80%) and in carcinoma of 9 cases (90%).
Conclusions: Breast carcinomas with Paget´s disease seem to be distinguished by the high expression of APC, cyclin B1, PTTG, c-erbB2, and cyclin D1 in contrast to breast cancers without Paget´s disease. Furthermore, the similar expression patterns of APC and APC regulatory proteins in both Paget´s disease and underlying breast cancer support the epidermotropic theory as its pathogenetic mechanism.
키워드
Paget´s disease;Breast cancer;Anaphase Promoting Complex;Cyclin B1;PTTG
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