정상대장점막, 샘종 및 대장암 병소에서 pS2/TFF1 단백발현에 관한 연구
Expression of pS2/TFF1 Protein in Normal Colonic Mucosa, Adenoma and Adenocarcinoma
채승완, 손진희, 김어진, 박영의, 조은윤,
소속 상세정보
채승완 ( Chae Seoung-Wan )
성균관대학교 의과대학 강북삼성병원 병리과학교실
손진희 ( Sohn Jin-Hee )
성균관대학교 의과대학 강북삼성병원 병리과학교실
김어진 ( Kim Eo-Jin )
성균관대학교 의과대학 강북삼성병원 병리과학교실
박영의 ( Park Young-Euy )
한림대학교 의과대학 병리학교실
조은윤 ( Cho Eun-Yoon )
성균관대학교 의과대학 강북삼성병원 병리과학교실
KMID : 0357920040380050324
Abstract
Background: The trefoil factor 1 protein (pS2/TFF1) is a candidate tumor-suppressor protein, and it is a pleiotropic factor involved in the organization and homeostasis of the gastrointestinal tract and various inflammatory or neoplastic diseases. The purpose of this study was to assess the expression of pS2/TFF1 and its clinicopathologic relationship, including the p53 and Ki-67 labeling index, in colorectal carcinogenesis.
Methods:expression of pS2/TFF1 protein was evaluated immunohistochemically in 45 samples of normal colonic mucosa, 43 samples of adenoma and 186 samples of colorectal carcinoma.
results: pS2/TFF1 protein was expressed weakly in 37.8% of normal colonic mucosa samples, and it had a weak to strong expression in 48.8% of adenomas and 28% of colorectal adenocarcinomas. pS2/ TFF1 expression in carcinoma was slightly increased in the poorly differentiated group compared with the well to moderately differentiated group (p=0.059). Interestingly, mucinous carcinoma (4/4) and signet ring cell carcinoma (2/3) showed significant increase of pS2/TFF1 expression. pS2/TFF1 expression was inversely correlated with the p53 protein expression and the Ki-67 labelling index (p<0.05). There was no significant correlation with the tumor size, metastasis or pathologic staging.
Conclusions: Overexpression of pS2/TFF1 expression in colorectal adenocarcinoma was inversely correlated with the Ki-67 labelling index and the p53 expression in cancer. These results suggest that pS2/TFF1 protein may contribute as tumor suppressor factor in colorectal adenocarcinoma.
키워드
TFF1 Protein;Colonic Neoplasm;Immunohistochemistry
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