Radiation-Induced Epithelial Proliferation Mimicking Invasive Carcinoma of the Urinary Bladder - A Report of 2 Cases -
이옥준, 김규래, 명나혜, 노재윤, 엄대운, 김현정,
소속 상세정보
이옥준 ( Lee Ok-Jun )
충북대학교 의과대학 병리학교실
김규래 ( Kim Kyu-Rae )
울산대학교 의과대학 서울아산병원 병리과
명나혜 ( Myung Na-Hye )
단국대학교 의과대학 병리학교실
노재윤 ( Ro Jae Y. )
울산대학교 의과대학 서울아산병원 병리과
엄대운 ( Eom Dae-Woon )
울산대학교 의과대학 서울아산병원 병리과
김현정 ( Kim Hyun-Jung )
울산대학교 의과대학 서울아산병원 병리과
KMID : 0357920040380050341
Abstract
Radiation-induced epithelial proliferation in the urinary bladder mimicking urothelial carcinoma has received only a little attention in the literature. Herein, we describe two cases of radiation-induced epithelial proliferative changes, which mimicked invasive urothelial carcinoma. Cystoscopy revealed bullous or edematous mucosal changes with multiple hemorrhagic foci. Microscopically, we observed inverted epithelial proliferation, forming nests and cords extending into the lamina propria. The epithelial cells in these nests and cords exhibited enlarged, hyperchromatic and pleomorphic nuclei, closely mimicking the infiltrative growth of urothelial carcinoma. However, the presence of radiation-induced changes was validated by the observation of abundant vacuolated cytoplasm, normal or slightly increased nuclear to cytoplasmic ratios, the absence of mitotic activity, dilated blood vessels containing frequent fibrin thrombi, scattered atypical fibroblasts, and the patients´ previous history of radiation treatment. Radiation-induced changes should be always included in differential diagnoses of proliferative epithelial lesions in the urinary bladder and a pertinent clinical history of radiotherapy should be searched.
키워드
Cystitis;Radiation Injuries;Urinary Bladder
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