Differential Expression of Promyelocytic Leukemia Protein in Autoimmune Liver Diseases
김현정, 유은실, 서동진, 김종재, 김정선, 이용상, Chung Hwa-Young, 이한주,
소속 상세정보
김현정 ( Kim Hyun-Jung )
인제대학교 의과대학 상계백병원 병리학교실
유은실 ( Yu Eun-Sil )
울산대학교 의과대학 서울아산병원 병리과
서동진 ( Suh Dong-Jin )
울산대학교 의과대학 서울아산병원 내과
김종재 ( Kim Jong-Jae )
서울대학교 의과대학 병리학교실
김정선 ( Kim Jung-Sun )
울산대학교 의과대학 서울아산병원 병리과
이용상 ( Lee Yong-Sang )
울산대학교 의과대학 서울아산병원 내과
( Chung Hwa-Young )
울산대학교 의과대학 서울아산병원 내과
이한주 ( Lee Han-Joo )
울산대학교 의과대학 서울아산병원 내과
KMID : 0357920040380060357
Abstract
Background: Promyelocytic leukemia protein (PML) is a primary biliary cirrhosis (PBC)-specific autoantigen. Anti-PML antibody is analyzed using cultured cells with patient sera, however, PML expression has rarely been examined in liver tissues.
Methods: In the present study, PML expression was examined immunohistochemically in paraffin embedded liver needle biopsy specimens obtained from 20 cases of PBC, 10 cases of autoimmune cholangitis, 36 cases of autoimmune hepatitis and from 5 cases of noninflammatory livers.
Results: Variable PML immunopositivity was detected in the bile duct epithelial cells of 18 (90.0%) of 20 PBC cases and in all 10 cases (100.0%) of autoimmune cholangitis, whereas it was only present in 6 (16.7%) of 36 cases of autoimmune hepatitis (p<0.001). In contrast, hepatocyte PML immunopositivity was higher in autoimmune hepatitis (33/36 cases, 90.8%), than in PBC (10/20 cases, 50.0%) or autoimmune cholangitis (3/10 cases, 30.0%) (p<0.05).
Conclusions: Our data indicate that the differential expression of PML is closely related to autoimmune liver diseases type, and suggest that the overexpression of PML protein in bile duct cells is associated with the development of autoantibodies in patients with PBC or autoimmune cholangitis. Furthermore, PML immunoreactivity may be useful for the diagnosis of autoimmune cholangitis and overlap syndrome.
키워드
Autoimmune diseases;Hepatitis;Primary biliary cirrhosis;Nuclear proteins;PML protein; human
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