CD24 Expression in Gastric Adenocarcinoma Is Associated with Tumor Invasiveness
정경천, 송헌호, 오권익, 신형식, Seo Jae-Nam, 박영의, 김태운, 최영미,
소속 상세정보
정경천 ( Jung Kyeong-Cheon )
한림대학교 의과대학 병리학교실
송헌호 ( Song Hun-Ho )
한림대학교 의과대학 내과학교실
오권익 ( Oh Kwon-Ik )
한림대학교 의과대학 병리학교실
신형식 ( Shin Hyung-Sik )
한림대학교 의과대학 병리학교실
( Seo Jae-Nam )
한림대학교 의과대학 병리학교실
박영의 ( Park Young-Euy )
한림대학교 의과대학 병리학교실
김태운 ( Kim Tae-Woon )
한림대학교 의과대학 병리학교실
최영미 ( Choi Young-Mi )
한림대학교 의과대학 병리학교실
KMID : 0357920040380060388
Abstract
Background: CD24, also referred to as the heat stable antigen in mice, is a glycosyl phosphatidylinositol-linked glycoprotein expressed by thymocytes, B cells, neutrophils and immature neuronal cells. It has been recently observed in a variety of human malignancy. Here, we demonstrated the expression of CD24 in gastric adenocarcinomas.
Methods: A total of 40 gastric adenocarcinomas and 20 tubular adenomas were immunohistochemically examined for the expression of CD24 and matrix metalloproteinase-2 (MMP-2) proteins. The immunoreactivity of CD24 was semiquantitatively scored (0, 1+, 2+) and compared with clinicopathologic variables and MMP-2 expression in tumor cells.
Results: CD24 was rarely expressed in normal gastric tissue and not expressed in tubular adenoma. In contrast, a moderate/strong expression (2+) of CD24 was observed in 25% of gastric adenocarcinomas, and 30% cases showed a weak CD24 staining (1+). Moreover, CD24 expression was significantly correlated with the depth of tumor invasion and MMP-2 expression.
Conclusions: These results suggest that the aberrant expression of CD24 in gastric adenocarcinomas might be associated with tumor progression and invasiveness.
키워드
CD24 antigen;Stomach neoplasms;Neoplasm invasiveness;Matrix metalloproteinase-2
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