Effect of Atorvastatin, a HMG-CoA Reductase Inhibitor, in Experimental Colitis in Mice
박효진, 오권익, 신형식, Seo Jae-Nam, 박영의, 김태운, 최은영,
소속 상세정보
박효진 ( Park Hyo-Jin )
서울대학교 의과대학 병리학교실
오권익 ( Oh Kwon-Ik )
한림대학교 의과대학 병리학교실
신형식 ( Shin Hyung-Sik )
한림대학교 의과대학 병리학교실
( Seo Jae-Nam )
한림대학교 의과대학 병리학교실
박영의 ( Park Young-Euy )
한림대학교 의과대학 병리학교실
김태운 ( Kim Tae-Woon )
한림대학교 의과대학 병리학교실
최은영 ( Choi Eun-Young )
서울대학교 의과대학 특수생명자원센터
KMID : 0357920040380060401
Abstract
Background: The statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are approved for cholesterol reduction, and may also be beneficial in the treatment of inflammatory disease. In this study, atorvastatin was tested in experimental colitis, a disease model of inflammatory bowel disease.
Methods: To induce colitis, dextran sodium sulfate (DSS) or trinitrobenzene sulfonic acid (TNBS) were administrated to C57BL/6 or BALB/c mice. Mice were monitored daily for loss of body weight and survival for indicated days. Colon length and histology were examined after sacrifice.
Results: The administration of DSS induced marked colonic inflammation and shortening, and resulted in a loss of body weight. DSS-induced colitis was not affected by atorvastatin treatment, but in contrast, the administration of atorvastatin relieved TNBS-induced colitis with a resultant rapid recovery of weight loss and a reduction in colonic length shortening. Histologically, inflammatory cell infiltration in the colonic wall, mucosal ulceration and crypt disruption were also suppressed in atorvastatin treated mice.
Conclusions: These results suggest that atorvastatin preserves intestinal integrity in colitis, probably via the modulation of Th cell-mediated immune response, in a manner independent of innate immunity.
키워드
Atorvastatin;inflammatiory bowel disease;Experimental colitis;Th cell mediated immunity;Immunity; Natural
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