유방조직에서 티로신 활성효소 수용체인 EphA2, c-met 및 c-erB-2의 발현
The Expressions of Tyrosine Kinase Receptors, EphA2, c-met and c-erbB-2 in the Human Breast
민수기, 박혜림, 신형식, 조현득, 염범우, 조성진, 박영의,
소속 상세정보
민수기 ( Min Soo-Kee )
한림대학교 의과대학 병리학교실
박혜림 ( Park Hye-Rim )
한림대학교 의과대학 병리학교실
신형식 ( Shin Hyung-Sik )
한림대학교 의과대학 병리학교실
조현득 ( Cho Hyun-Deuk )
한림대학교 의과대학 병리학교실
염범우 ( Yeom Bom-Woo )
고려대학교 의과대학 병리학교실
조성진 ( Cho Seong-Jin )
한림대학교 의과대학 병리학교실
박영의 ( Park Young-Euy )
한림대학교 의과대학 병리학교실
KMID : 0357920050390010015
Abstract
Background:osine kinase receptor (TKR) is an important protein for normal-development, growth and tumorigenesis in human tissues. The purpose of this study was to evaluate the effect of TKR in the progression of breast cancer.
methods: The expressions of EphA2, c-met and c-erbB-2 were examined, by using immunohistochemical methods and RT-PCR, in samples of breast tissue that included 111 samples of normal epithelium, 34 samples of ductal carcinoma in situ (DCIS), and 109 samples of invasive ductal carcinomas (IDC). The results were compared with the prognostic parameters of breast cancer including the tumor grade, growth pattern, lymph node metastasis and the expressions of ER, PR, p53 and Ki-67.
Results: The protein expressions of the three TKRs were higher in DCIS and IDC than in normal epithelium. The protein expression of EphA2 was correlated with a tumor grade, a labeling index of Ki-67, and the protein expression of c-met. Overexpression of c-erbB-2 was correlated with lymph node metastasis. The mRNA levels of the three TKRs were correlated with each other in normal tissue and IDC. The level of c-met mRNA was higher in the low grade tumors.
Conclusions: The three TKRs may play roles in the tumorigenesis of human breast cancer. The overexpressions of EphA2 and c-erbB-2 may be a poor prognostic parameter in breast cancers.
키워드
EphA2;c-met;erbB-2;Tyrosine kinase receptors;Breast cancer
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