유두 갑상샘암종의 체모양-오디모양 변형 -2예보고-
Cribriform-Morular Variant of Papillary Thyroid Carcinoma -A Report of Two Cases-
심영란, 배영경, 김미진, 최준혁, 최원희,
소속 상세정보
심영란 ( Shim Young-Ran )
영남대학교 의과대학 영천병원 병리과
배영경 ( Bae Young-Kyung )
영남대학교 의과대학 병리학교실
김미진 ( Kim Mi-Jin )
영남대학교 의과대학 병리학교실
최준혁 ( Choi Joon-Hyuk )
영남대학교 의과대학 병리학교실
최원희 ( Choi Won-Hee )
영남대학교 의과대학 병리학교실
KMID : 0357920050390010048
Abstract
Cribriform-morular variant of papillary thyroid carcinoma is an unusual and peculiar subtype of papillary thyroid carcinomas. It occurs both sporadically and in association with familial adenomatous polyposis. We report here on two cases of cribriform-morular variant of papillary thyroid carcinoma in a 33-year-old woman and in a 21-year-old woman. On gross examination, both cases were multicentric. The first case showed two well-encapsulated yellow solid masses in the right (2.0 cm) and the left lobes of the thyroid gland (0.5 cm). The second case showed four well-encapsulated gray-white solid lobulating masses and nodules in the right (4.5 and 1.2 cm) and the left lobes (1.1 and 0.8 cm) of the thyroid gland. Microscopically, both cases exhibited an intricate blending of papillary, cribriform, trabecular, spindle, and solid patterns of growth with morular areas. Typical nuclear features of papillary carcinomas were focally seen. Immunohistochemically, the tumor cells were positive for thyroglobulin, thyroid transcription factor-1 (TTF-1), and -catenin, but were negative for calcitonin.
키워드
Cribriform-morular variant;Papillary carcinoma;Thyroid gland
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