Expression of p63, bcl-2, bcl-6 and p16 in Basal Cell Carcinoma and Squamous Cell Carcinoma of the Skin
Zheng Zhen-Long, 김애리, 계영철, 김인선, Zhang Xiang-Lan,
소속 상세정보
( Zheng Zhen-Long )
고려대학교 의과대학 병리학교실
김애리 ( Kim Ae-Ree )
고려대학교 의과대학 병리학교실
계영철 ( Kye Young-Chul )
고려대학교 의과대학 피부과학교실
김인선 ( Kim In-Sun )
고려대학교 의과대학 병리학교실
( Zhang Xiang-Lan )
고려대학교 의과대학 병리학교실
KMID : 0357920050390020091
Abstract
Background: Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the common malignant neoplasms of the skin. The p63 is a p53 homologue which is considered to be a reliable keratinocyte stem cell marker. Bcl-2 plays a key role in cell longevity by preventing apoptosis, whereas the bcl-6 gene functions as a transcriptional repressor. The p16-CDK4/6 complex arrests the cell cycle at G0/G1 phase. In the present study, the expression of p63, bcl-2, bcl-6, and p16 in BCC and SCC was evaluated.
Methods: Forty-seven BCCs and 43 SCCs were selected and microarrayed in paraffin blocks. Immunohistochemical analysis was performed with specific antibodies for bcl-2, bcl-6, p16 and p63.
Results: p63 was found to be expressed in all BCCs and SCCs. Bcl-2 was exclusively expressed in BCCs (100%), but there was negative expression in SCCs, whereas bcl-6 was positively expressed in 18.2% of SCCs, and was negative in BCCs. In SCCs, p16 was expressed at high frequency (47.7%) than in BCCs (14.9%). The expression of p16 was correlated with the histologic grades of SCCs.
Conclusion: The different patterns of bcl-2, bcl-6, p63 and p16 protein expression between BCCs and SCCs may represent the different histogenesis and morphologic features of two lesions.
키워드
Carcinoma;Basal cell;Squamous cell;p63 protein;Proto-oncogene proteins bcl-2;Proto-oncogene protein bcl-6; Protein 16
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