Expression of Vascular Endothelial Growth Factors A, C and D in Gastric Adenocarcinoma
정명자, 장규윤, 이동근, 양두현, 강명재, 문우성, 이진욱, 유기훈,
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정명자 ( Chung Myoung-Ja )
전북대학교 의과대학 병리학교실
장규윤 ( Jang Kyu-Yun )
전북대학교 의과대학 병리학교실
이동근 ( Lee Dong-Geun )
전북대학교 의과대학 병리학교실
양두현 ( Yang Doo-Hyun )
전북대학교 의과대학 외과학교실
강명재 ( Kang Myoung-Jae )
전북대학교 의과대학 병리학교실
문우성 ( Moon Woo-Sung )
전북대학교 의과대학 병리학교실
이진욱 ( Lee Jin-Wook )
전북대학교 의과대학 병리학교실
유기훈 ( Yu Ki-Hoon )
전북대학교 의과대학 병리학교실
KMID : 0357920050390020099
Abstract
Background: Vascular endothelial growth factor (VEGF)-C and VEGF-D are novel growth factors that regulate lymphatic vessel growth. This study was designed to examine whether the expression of three VEGF family members, VEGF-A, VEGF-C and VEGF-D are associated with the clinicopathologic parameters, especially with lymph node metastasis, in advanced gastric carcinomas.
Methods: Immunohistochemical staining was performed for VEGF-A, VEGF-C, and VEGF-D in the surgically resected specimens from 102 patients with advanced gastric carcinoma. The mRNA expressions of the three VEGF family members were assessed in 16 cases of tumor tissues and their corresponding non-neoplastic tissues.
Results: Of the 102 gastric carcinomas, 74 (73%), 82 (80%), and 34 (33%) cases showed cytoplasmic immuno-reactivity for VEGF-A, VEGF-C and VEGF-D, respectively. Both VEGF-A and VEGF-C expressions were associated with lymphatic invasion and lymph node metastasis (p<0.05), but the VEGF-D expression was not associated with them (p>0.05). In the tumor tissue, VEGF-C mRNA expression was greater, while VEGF-D mRNA expression was lower than in the non-neoplatic tissue adjacent to the tumor.
Conclusions: VEGF-A and VEGF-C may play important roles for the lymphatic spread of gastric carcinoma. We suggest that neutralizing both VEGF-A and VEGF-C may be reguired to block lymph node metastasis.
키워드
Vascular endothelial growth factor-A;Vascular endothelial growth factor-C;Vascular endothelial growth factor-D; Stomach; Adenocarcinoma
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