비소세포 폐암종에서 Survivin의 발현 - 예후 및 종양 표지자와의 상관성 -
Expression of Survivin in Non-Small Cell Lung Carcinoma: Relationship to Tumor Biology and Prognosis in Surgically Treated Patients
정민정, 천봉권,
소속 상세정보
정민정 ( Jung Min-Jung )
고신대학교 의과대학 병리학교실
천봉권 ( Chun Bong-Kwon )
고신대학교 의과대학 병리학교실
KMID : 0357920050390030151
Abstract
Background: Survivin, a novel member of inhibitor-of-apoptosis, is undetectable in most terminally differentiated nonproliferative adult tissue, but is overexpressed in some human malignancies. The survivin gene expression is repressed by binding of wild-type p53 with the survivin promotor. In this study, we investigated the prevalence of survivin expression, its association with p53 overexpression and proliferative index, and clinicopathological significance in non-small cell lung carcinomas (NSCLC).
Methods: Immunohistochemical stainings were performed in 59 cases of primary NSCLC for survivin, p53 and Ki-67. Correlations between the survivin expression, p53 overexpression and Ki-67 labeling index were analyzed.
Results: Survivin expression was detected in 47 carcinomas (80%) with nuclear immunoreactivity (56%). Survivin nuclear immunoreactivity revealed significantly worse prognosis in NSCLC patients (p=0.003), and correlated with lymph node metastasis (p=0.014), lymphovascular invasion (p=0.032), p53 overexpression, and Ki-67 labeling index (KI 24.2±6.9, p=0.045). Survivin expression was not correlated with histological type and pT status.
Conclusions: High incidence of survivin overexpression in NSCLC suggests that survivin is involved in lung carcinogenesis, and nuclear expression of survivin can be used as a poor prognostic predictor in NSCLC patients. Expression of mutant p53 seems to be a possible mechanism of survivin up-regulation in NSCLC.
키워드
Survivin protein;p53 protein;Cell proliferation;Carcinoma; non-small-cell lung
원문 및 링크아웃 정보
등재저널 정보