Differential Expression of CD34 and Smooth Muscle Actin in the Stroma of Small Lung Adenocarcinoma with Mixed Bronchioloalveolar and Invasive Components
노미숙, 박태호, 이창훈, 이현욱, 최필조, 최종우, 권혁찬, Cheon Bong-Kwon,
소속 상세정보
노미숙 ( Roh Mee-Sook )
동아대학교 의과대학 병리학교실
박태호 ( Park Tae-Ho )
동아대학교 의과대학 내과학교실
이창훈 ( Lee Chang-Hun )
부산대학교 의과대학 병리학교실
이현욱 ( Lee Hyoun-Wook )
동아대학교 의과대학 병리학교실
최필조 ( Choi Phil-Jo )
동아대학교 의과대학 흉부외과학교실
최종우 ( Choi Jong-Woo )
동아대학교 의과대학 병리학교실
권혁찬 ( Kwon Hyuk-Chan )
동아대학교 의과대학 내과학교실
( Cheon Bong-Kwon )
고신대학교 의과대학 병리학교실
KMID : 0357920050390030158
Abstract
Background: Absence of CD34-positive fibroblasts was reported within the stroma associated with invasive carcinomas. Conversely, tumor-associated desmoplastic stroma is characterized by the presence of smooth muscle actin (SMA)-reactive myofibroblasts. The present study was undertaken in order to elucidate whether the different distributions of stromal CD34-positive fibroblasts and SMA-reactive myofibroblasts are sensitive or specific markers of tumor invasion in small lung adenocarcinomas.
Methods: Immunohistochemical stainings for CD34 and SMA were done in 37 peripheral adenocarcinomas less than 3.0 cm in diameter, including 16 adenocarcinomas with bronchioloalveolar carcinoma (BAC) and invasive components (mixed), and 21 invasive adenocarcinomas without BAC components (invasive).
Results: The fibroblasts within the BAC components of the mixed group were mainly CD34-positive (81.2%) and preferentially SMA-negative (56.3%). In contrast, the fibroblasts within the invasive components of the mixed group were mainly CD34-negative (75.0%) and SMA-positive (87.5%). The stromal cells of the invasive group were mostly negative for CD34 (90.5%) and positive for SMA (95.3%).
Conclusions: The loss of CD34 and the acquisition of SMA in the stromal cells within the tumor were related to tumor invasion (p<0.05). Thus, expression patterns of CD34 and SMA can be used to detect small foci of early stromal invasion in adenocarcinomas of the lung.
키워드
Antigens;CD34;Smooth muscle actin;Neoplasm invasiveness;Adenocarcinoma;Lung
원문 및 링크아웃 정보
등재저널 정보