육아종성 유방염의 임상 및 병리학적 특성
Clinicopathologic Features of Granulomatous Mastitis
김의정, 최윤정, 김도일, 김지영, 김희정, 박양순, 홍순원, 박찬일, 정우희, 이희대,
소속 상세정보
김의정 ( Kim Yee-Jeong )
미즈메디병원 병리과
최윤정 ( Choi Yoon-Jung )
국민건강보험공단 일산병원 병리과
김도일 ( Kim Do-Yil )
미즈메디병원 외과
김지영 ( Kim Ji-Young )
포천중문의과대학교 강남차병원 병리과
김희정 ( Kim Hee-Jung )
미즈메디병원 병리과
박양순 ( Park Yang-soon )
미즈메디병원 병리과
홍순원 ( Hong Soon-Won )
연세대학교 의과대학 영동세브란스병원 병리과
박찬일 ( Park Chan-Il )
연세대학교 의과대학 영동세브란스병원 병리과
정우희 ( Jung Woo-Hee )
연세대학교 의과대학 영동세브란스병원 병리과
이희대 ( Lee Hy-De )
연세대학교 의과대학 영동세브란스병원 외과학교실
KMID : 0357920050390030181
Abstract
Background: Granulomatous mastitis (GM) is a rare chronic inflammatory condition that clinically mimics a carcinoma. The diagnosis of idiopathic GM depends on the exclusion of other granulomatous inflammations. The purpose of this study is to correlate the clinicopathological features of GM with etiologies.
Methods: We reviewed the clinical records of 58 cases that were histologically diagnosed as GM. We performed special stains for microorganisms such as Ziehl-Neelsen, periodic acid Schiff and gram stains, and polymerase chain reaction (PCR) for Mycobacterium tuberculosis (TB PCR).
Results: The mean age of patients was 35.3 years. Most patients were parous except three. Seven patients (12.1%) were related with pregnancy or lactation. TB PCR was positive in nine patients (15.5%). Five patients (8.6%) had gram positive bacilli that were recognizable as coryneform bacteria. Culture study demonstrated Staphylococcus aureus in only one case. Infectious GM had a greater tendency to form abscesses. Fat necrosis was more likely to be present in idiopathic GM, but other histological features were similar to each other. Twenty-two cases (37.9%) showed recurrence.
Conclusions: We suggest that TB PCR and gram stain are essential tests for the differential diagnosis of GM, because the histologic features considerably overlap irrespective of the various etiologies.
키워드
Granuloma;Mastitis;Tuberculosis;Corynebacterium;Polymerase chain reaction
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