곧창자 샘암종에서 p53, bcl-2, Ki-67 발현과 세포자멸사에 대한 연구:수술 전 방사선화학 치료 반응과의 상관관계
An Analysis of p53, bcl-2 and Ki-67 Expressions, and Apoptosis in Rectal Cancer: Their Correlation with the Tumor Response after Preoperative Radiochemotherapy
유진영, 김성환, 전정수, 강창석, 진형민, 강석진, 김수지, 조현민, 김준기, 이정용,
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유진영 ( Yoo Jin-Young )
가톨릭대학교 의과대학 임상병리학교실
김성환 ( Kim Sung-Hwan )
가톨릭대학교 의과대학 방사선종양학교실
전정수 ( Chun Chung-Soo )
가톨릭대학교 의과대학 외과학교실
강창석 ( Kang Chang-Suk )
가톨릭대학교 의과대학 임상병리학교실
진형민 ( Chin Hyung-Min )
가톨릭대학교 의과대학 외과학교실
강석진 ( Kang Seok-Jin )
가톨릭대학교 의과대학 임상병리학교실
김수지 ( Kim Su-Zy )
가톨릭대학교 의과대학 방사선종양학교실
조현민 ( Cho Hyeon-Min )
가톨릭대학교 의과대학 외과학교실
김준기 ( Kim Jun-Ki )
가톨릭대학교 의과대학 외과학교실
이정용 ( Lee Jung-Yong )
가톨릭대학교 의과대학 임상병리학교실
KMID : 0357920050390040222
Abstract
Background: Preoperative radiochemotherapy (RCT) has been administered for locally advanced rectal cancer to increase the therapeutic benefits, and to preserve the sphincter in low-lying tumors, however, tumor responses after RCT are variable.
Methods: Apoptotic index (AI), and expressions of Ki-67, p53 and bcl-2 were analyzed in pretreatment biopsies from 69 patients with rectal cancer by immunohistochemistry. Tumor response was graded in surgically resected specimens by using a three-scale grading system: no response (NR), partial remission (PR) and complete remission (CR).
Results: CR was identified in 19 cases (28%), PR in 24 cases (35%), and NR in 26 cases (38%) of 69 cases. p53 protein was expressed in 49 cases (71%), whereas bcl-2 was in 42 cases (61%). The pretreatment Ki-67 labeling index was 65.4±23.4%. The tumor response was not associated with any of these markers. Tumors with CR/PR showed a higher AI (0.84±0.84%/0.66±0.52%) than that of tumors with NR (0.58±0.54%). There was a significant correlation between tumor response and the histologic differentiation (p=0.008) or recurrence (p=0.039).
Conclusions: The AI revealed a tendency to increase in tumors with CR/PR, while expressions of p53 and bcl-2, and Ki-67 labeling index had little direct association with tumor response.
키워드
Rectal neoplasms;Protein; p53;bcl-2 protein antigen;Ki-67 protein antigen;Apoptosis
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