간내선암종 감별을 위한 종양표지단백의 발현 양상
Expression Patterns of Tumor Related Proteins for Differential Diagnoses of Intrahepatic Adenocarcinomas
윤길숙, 배한익, 김태숙, 김미성, 이영화, 엄지현, 김선주, 서인수,
소속 상세정보
윤길숙 ( Yun Kil-Suk )
경북대학교 의과대학 병리학교실
배한익 ( Bae Han-Ik )
경북대학교 의과대학 병리학교실
김태숙 ( Kim Tae-Sook )
인하대학교 의과대학 병리학교실
김미성 ( Kim Mi-Sung )
경북대학교 의과대학 병리학교실
이영화 ( Lee Young-Hwa )
경북대학교 의과대학 병리학교실
엄지현 ( Uhm Ji-Hyun )
경북대학교 의과대학 병리학교실
김선주 ( Kim Sun-Joo )
경북대학교 의과대학 병리학교실
서인수 ( Suh In-Su )
경북대학교 의과대학 병리학교실
KMID : 0357920050390040229
Abstract
Background: Differential diagnoses of intrahepatic adenocarcinomas (IHAC) play an important role in the detecting primary sites and the determining type of treatment and overall prognosis of the patient. However, histopathologic findings alone have limitations of differential diagnoses of IHAC.
Methods: To clarify which tumor related proteins (TRP) are useful for differential diagnoses of IHAC, TRP expression were investigated immunohistochemically, using MUC5AC, MUC2, mAb 91.9H, MUC1, and pS2, and by high iron diamine (HID) staining in 61 clinically confirmed IHACs.
Results: MUC5AC (9/18, p<0.05) and MUC1 (17/18, p>0.05) displayed the most frequent expression in cholangiocarcinomas, and MUC2 (11/18, p<0.05), mAb 91.9H (16/18, p<0.05), and HID (16/18, p<0.05) in colorectal adenocarcinomas. pS2 (3/11, p>0.05) was expressed more often in pancreatic adenocarcinomas than other IHAC, while MUC2 and 91.9H were not expressed at all in pancreatic adenocarcinomas. The positivity of several TRP did not correlate with tumor differentiation.
Conclusions: MUC5AC, MUC2, mAb 91.9H, and HID may be useful in differentiating cholangiocarcinomas from colorectal adenocarcinomas.
키워드
Cholangiocarcinoma;Metastatic adenocarcinoma;MUC5AC;MUC2 MUC1;mAb91.9H;pS2;HID
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