대장의 샘종 및 샘암종에서 Osteopontin, ZO-1 및 E-cadherin의 발현
Expression of Osteopontin, ZO-1 and E-cadherin in Adenoma and Adenocarcinoma of the Colon
정유경, 이미자, 전호종, 임성철, 기근홍, 서재홍,
소속 상세정보
정유경 ( Jeong Yu-Kyung )
중앙대학교 의과대학 병리학교실
이미자 ( Lee Mi-Ja )
조선대학교 의과대학 병리학교실
전호종 ( Jeon Ho-Jong )
조선대학교 의과대학 병리학교실
임성철 ( Lim Sung-Chul )
조선대학교 의과대학 병리학교실
기근홍 ( Kee Keun-Hong )
조선대학교 의과대학 병리학교실
서재홍 ( Suh Chae-Hong )
조선대학교 의과대학 병리학교실
KMID : 0357920050390040242
Abstract
Background: The expressions of osteopontin (OPN), zonula occludens-1 (ZO-1) and E-cadherin, known as cell adhesion-associated substances, were examined in adenoma and adenocarcinoma of the colon. The relationship of their expressions with clinicopathologic factors was examined to investigate the roles of these proteins in the development, invasion or metas- tasis of colon adenocarcinoma.
Methods: The expressions of OPN, ZO-1, and E-cadherin were examined in 54 cases of adenoma and 67 cases of adenocarcinoma of the colon by immunohistochemical staining.
Results: The expression of OPN in colon adenocarcinoma correlated with staging (p=0.012) and distant metastasis (p=0.021). The expression of ZO-1 was closely related with tumor cell differentiation (p<0.001), and the reduced expression of E-cadherin was associated with tumor cell differentiation (p=0.05) and lymph node metastasis (p<0.001). Co-expression of ZO-1 and E-cadherin was significantly associated with tumor cell differentiation, and the expressions of ZO-1 and E-cadherin were reduced or lost in all cases (5 cases) of poorly differentiated adenocarcinoma.
Conclusions: Our data suggest that OPN is involved in the process of invasion and metastasis of colon adenocarcinoma, and ZO-1- and E-cadherin-mediated cell adhesion may play an important role in the differentiation of colon adenocarcinoma.
키워드
Colon;Adenocarcinoma;Osteopontin;Zonula occludens-1 protein;E-cadherin
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