Expression of Actin-bundling Protein Fascin and its Relationship with Altered E-cadherin and β-catenin Expressions in Ovarian Serous Neoplasms
조은윤, 안긍환, 김계현, 손진희, 채승완, 최윤라, 김어진,
소속 상세정보
조은윤 ( Cho Eun-Yoon )
성균관대학교 의과대학 삼성서울병원 병리학교실
안긍환 ( Ahn Geung-hwan )
성균관대학교 의과대학 삼성서울병원 병리학교실
김계현 ( Kim Kye-Hyun )
성균관대학교 의과대학 강북삼성병원 산부인과학교실
손진희 ( Sohn Jin-Hee )
성균관대학교 의과대학 강북삼성병원 병리과학교실
채승완 ( Chae Seoung-Wan )
성균관대학교 의과대학 강북삼성병원 병리과학교실
최윤라 ( Choi Yoon-La )
성균관대학교 의과대학 삼성서울병원 병리학교실
김어진 ( Kim Eo-Jin )
성균관대학교 의과대학 강북삼성병원 병리과학교실
KMID : 0357920050390040258
Abstract
Background: Fascin, an actin-bundling protein, has been found in specialized normal cells, including the neuronal, endothelial and dendritic cells, and its expression is known to be greatly increased in various human neoplasms.
Methods: Immunohistochemical stainings for fascin, β-catenin, and E-cadherin were performed in normal ovary tissue (n=13), and in benign (n=14), borderline (n=32), and malignant (n=74) ovarian serous neoplasms. We evaluated the fascin expression, and its relationship with the β-catenin and E-cadherin expressions, as well as the clinicopathologic factors.
Results: Fascin expression was detected in the majority of the borderline (100%, 32/32) and malignant tumors (90.5%, 67/74), but it was not seen in the normal ovarian surface epithelial cells and the benign tumors (p<0.001). Fascin expression was significantly correlated with the occurrence of peritoneal metastases in the carcinomas (p=0.043). A significant relationship between the expressions of fascin and β-catenin (p=0.046), as well as E-cadherin (p=0.035) was noted. There was no significant correlation with the tumor grade of carcinoma, the FIGO stage, tumor recurrence, tumor-related death and the survival rate.
Conclusions: In ovarian serous neoplasms, the fascin expression may be closely linked with tumor progression and metastasis, and it was associated with the up-regulation of β-catenin and E-cadherin.
키워드
Ovary; Serous neoplasms;Fascin;Metastasis
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