IgA 신증과 동반된 막사구체신염 - 6예 보고 -
Combined IgA Nephropathy and Membranous Glomerulonephritis - A Report of Six Cases -
정지한, 김용수, 장윤식, 방병기, 강창석, 심상인, 최영진,
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정지한 ( Jung Ji-Han )
가톨릭대학교 의과대학 임상병리학교실
김용수 ( Kim Yong-Soo )
가톨릭대학교 의과대학 내과학교실
장윤식 ( Chang Yoon-Sik )
가톨릭대학교 의과대학 내과학교실
방병기 ( Bang Byung-Kee )
가톨릭대학교 의과대학 내과학교실
강창석 ( Kang Chang-Suk )
가톨릭대학교 의과대학 임상병리학교실
심상인 ( Shim Sang-In )
가톨릭대학교 의과대학 임상병리학교실
최영진 ( Choi Yeong-Jin )
가톨릭대학교 의과대학 임상병리학교실
KMID : 0357920050390040278
Abstract
IgA nephropathy (IgAN) and membranous glomerulonephritis (MGN) are common in adults. However, it is unlikely that these two distinct glomerulonephrites coexist in a renal biopsy. Here, we report clinical and pathological data of six patients with concomitant existence of IgAN and MGN in renal biopsy specimens from 1990 to 2004. Five patients were male and one was female, and their ages ranged from 29 to 71 years. Four patients had microscopic hematuria, five had nephrotic range proteinuria, three had hepatitis B virus infections, three had rheumatoid factors, one had antinuclear antibodies. Two cases were developed after kidney transplant. Immunofluorescence microscopy showed characteristic findings of mesangial IgA deposits and granular IgG deposits on the capillary walls. These were confirmed by electron microscopic findings of immune-type electron-dense deposits in the mesangium and subepithelial capillary basement membranes. The pathogenesis and prognosis of the patients are discussed in this report.
키워드
IgA nephropathy;Membranous glomerulonephritis;Hepatitis B virus;Rheumatoid factor
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