방사선요법으로 치료한 자궁목의 침윤성 편평세포암종에서 HIF-1 단백 발현
Expression of Hypoxia Inducible Factor-1 in Invasive Squamous Cell Carcinoma of Uterine Cervix Treated by Radiotherapy
이경자, 유은선, 박수연, 박혜숙, 서현숙, 김성철, 심기남, 정성애, 유권, 성순희, 조민선, 이시내, 박혜영, 문혜성, 이경은,
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이경자 ( Lee Kyung-Ja )
이화여자대학교 의과대학 방사선종양학교실
유은선 ( Yoo Eun-Sun )
이화여자대학교 의과대학 소아과학교실
박수연 ( Park Soo-Yeun )
이화여자대학교 의과대학 해부학교실
박혜숙 ( Park Hye-Sook )
이화여자대학교 의과대학 예방의학교실
서현숙 ( Suh Hyun-Suk )
이화여자대학교 의과대학 방사선종양학교실
김성철 ( Kim Seung-Cheol )
이화여자대학교 의과대학 산부인과학교실
심기남 ( Shim Ki-Nam )
이화여자대학교 의과대학 내과학교실
정성애 ( Jung Sung-Ae )
이화여자대학교 의과대학 내과학교실
유권 ( Yoo Kwon )
이화여자대학교 의과대학 내과학교실
성순희 ( Sung Sun-Hee )
이화여자대학교 의과대학 병리학교실
조민선 ( Cho Min-Sun )
이화여자대학교 의과대학 병리학교실
이시내 ( Lee Shi-Nae )
이화여자대학교 의과대학 병리학교실
박혜영 ( Park Hae-Young )
이화여자대학교 의과대학 생화학교실
문혜성 ( Moon Hye-Sung )
이화여자대학교 의과대학 산부인과학교실
이경은 ( Lee Kyung-Eun )
이화여자대학교 의과대학 내과학교실
KMID : 0357920050390050307
Abstract
Background: Hypoxia-inducible factor-1 (HIF-1 ) is an intrinsic marker of tumor hypoxia, and this is associated with reduced radiosensitivity. Furthermore, HIF-1 can increase a tumor´´s aggressiveness by promoting neoangiogenesis, cell proliferation and survival, and invasion.
Methods: The expression of HIF-1 was was investigated by performing immunohistochemistry on the cervical tissue specimens obtained from 57 patients who had received radiotherapy combined with or without chemotherapy for stages I-III cervical squamous cell carcinoma. The staining results were compared with anemia, the stage, the radiotherapy response and patient survival by univariate and multivariate analysis.
Results: In 57 patients, the expression of HIF-1 was seen in the tissue specimens of 46 patients (81.7%). Among them, 25 (54.3%), 14 (30.4%), and 7 (15.2%) of the patients´´ tissue specimens showed weak, moderate and strong expressions, respectively. Six patients had a partial response after radiotherapy. Twelve patients (21.1%) died of cervical cancer. The increased expression of HIF-1 was significantly associated (p<0.05) with the disease stage and anemia. There were significant positive correlations between the increased expression of HIF-1 and the poor response after radiotherapy and the patients´´ survival.
Conclusions: The present result suggests that the overexpression of HIF-1 in the uterine cervix could be used as a prognostic indicator for the patients treated with radiotherapy.
키워드
Cervix Neoplasms;Carcinoma; Squamous cell;Hypoxia Inducible Factor 1;Immunohistochemistry
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