Survivin and Fas Ligand Expressions Are Correlated with Angiolymphatic Tumor Spread in Medullary Thyroid Carcinoma
김민경, 박성혜, 주미, 손진희, 채승완, 박성호, 김한성, 김어진,
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김민경 ( Kim Min-Kyoung )
성균관대학교 의과대학 강북삼성병원 병리과학교실
박성혜 ( Park Sung-Hye )
서울대학교 의과대학 병리학교실
주미 ( Joo Mee )
인제대학교 의과대학 일산백병원 병리과
손진희 ( Sohn Jin-Hee )
성균관대학교 의과대학 강북삼성병원 병리과학교실
채승완 ( Chae Seoung-Wan )
성균관대학교 의과대학 강북삼성병원 병리과학교실
박성호 ( Park Seong-Hoe )
서울대학교 의과대학 병리학교실
김한성 ( Kim Han-Seung )
인제대학교 의과대학 일산백병원 병리과
김어진 ( Kim Eo-Jin )
성균관대학교 의과대학 강북삼성병원 병리과학교실
KMID : 0357920050390050320
Abstract
Background: Medullary thyroid carcinoma (MTC) that originates from C cells comprises about 10% of all the malignant thyroid tumors. Activating mutations of the RET proto-oncogene have been found to be involved in the anti-apoptotic pathway of MTC that harbors the RET mutation. We investigated the correlation between the clinicopathologic parameters and the expressions of survivin, a novel anti-apoptotic molecule, and the other apoptosis-related proteins, and the known prognostic markers.
Methods: Immunohistochemical staining was performed using antibodies for survivin, Fas, Fas ligand (FasL), bcl-2, calcitonin, CEA and cyclin A in 19 case of MTC; 10 sporadic MTCs, eight multiple endocrine neoplasia (MEN) type 2A MTCs and one
familial MTC (FMTC).
Results: Survivin protein expression was found in five cases (26%) and this was correlated with the presence of angiolymphatic tumor emboli (p=0.019). FasL was expressed in 14 cases (74%) and it had correlation with the presence of lymph node metastases (p=0.029). The cyclin A-labeling indices were correlated with local invasiveness (p=0.001).
Conclusions: Survivin and FasL might be involved in the lymphatic tumor spread of MTC.
키워드
Survivin protein;Thyroid gland;Carcinoma;medullary
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