Histiocytic Sarcoma of the Spleen : A Case Report and Review of the Literature
백진호, 김지은, 전윤경, 김철우, 민혜숙, 김영아, 박성신,
소속 상세정보
백진호 ( Paik Jin-Ho )
서울대학교 의과대학 병리학교실
김지은 ( Kim Ji-Eun )
서울대학교 의과대학 보라매병원 병리과
전윤경 ( Jeon Yoon-Kyung )
서울대학교 의과대학 병리학교실
김철우 ( Kim Chul-Woo )
서울대학교 의과대학 병리학교실
민혜숙 ( Min Hye-Sook )
서울대학교 의과대학 병리학교실
김영아 ( Kim Young-A )
서울대학교 의과대학 보라매병원 병리과
박성신 ( Park Sung-Shin )
동국대학교 의과대학 병리학교실
KMID : 0357920050390050356
Abstract
True histiocytic sarcoma is an extremely rare tumor. Its clinicopathological features are not clearly understood. Here, we report the first Korean case of primary splenic histiocytic sarcoma. A 64-year-old female having refractory thrombocytopenia, anemia and splenic mass was admitted to the hospital, and received splenectomy. Grossly, spleen was enlarged up to 18×13×8cm and occupied with multinodular masses. Microscopically, the masses were composed of atyical large cells with abudant cytoplasm and vesicular nuclei with prominent hemophagocytosis. The tumor cells were CD68 (+), S-100 protein (-), CD21 (-), CD1a (-). After splenectomy, thrombocytopenia and anemia were corrected. However two months later the symptoms recurred, and the patient died 15 months after splenectomy. This case shared the common clinicopathologic features with the several previously reported cases in other countries, represented by splenic mass formation and prominent hemophagocytosis associated with thrombocytopenia and anemia, often leading to poor outcome.
키워드
Histiocytic sarcoma;Spleen;Thrombocytopenia
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