À¯¹æ¾ÏÁ¾¿¡¼ Vascular Endothelial Growth Factor-C ¹ßÇö
Expression of Vascular Endothelial Growth Factor-C in Breast Carcinoma
Á¤¸íÀÚ, Àå±ÔÀ±, À̵¿±Ù, °¸íÀç, ¾ç¼±È£, ¹®¿ì¼º,
¼Ò¼Ó »ó¼¼Á¤º¸
Á¤¸íÀÚ ( Chung Myoung-Ja )
ÀüºÏ´ëÇб³ ÀÇ°ú´ëÇÐ º´¸®Çб³½Ç
Àå±ÔÀ± ( Jang Kyu-Yun )
ÀüºÏ´ëÇб³ ÀÇ°ú´ëÇÐ º´¸®Çб³½Ç
À̵¿±Ù ( Lee Dong-Geun )
ÀüºÏ´ëÇб³ ÀÇ°ú´ëÇÐ º´¸®Çб³½Ç
°¸íÀç ( Kang Myoung-Jae )
ÀüºÏ´ëÇб³ ÀÇ°ú´ëÇÐ º´¸®Çб³½Ç
¾ç¼±È£ ( Yang Sun-Ho )
ÀüºÏ´ëÇб³ ÀÇ°ú´ëÇÐ ÀçÈ°ÀÇÇб³½Ç
¹®¿ì¼º ( Moon Woo-Sung )
ÀüºÏ´ëÇб³ ÀÇ°ú´ëÇÐ º´¸®Çб³½Ç
KMID : 0357920050390060401
Abstract
Background: Vascular endothelial growth factor-C (VEGF-C) is a novel growth factor that regulates lymphangiogenesis and/or angiogenesis via binding to the vascular endothelial growth factor receptor-3 (VEGFR-3) or VEGFR-2. Recent studies have suggested that VEGF-C may play a role in lymph node metastasis. This study was conducted to examine whether the expression of VEGF-C is associated with the clinicopathologic parameters, and especially lymph node metastasis, of invasive ductal carcinoma.
Methods: Immunohistochemical staining was performed for VEGF-C and CD31 in the surgically resected specimens from 83 patients with invasive breast carcinoma.
Results: Of the 83 breast carcinomas, 61 (74%) cases showed cytoplasmic VEGF-C immunoreactivity. VEGF-C expression was associated with lymph node metastasis (p=0.03), but it did not correlate with tumor size, the histologic grade, and the presence of estrogen receptor or progesteron receptor. The mean microvessel density in the cases without VEGF-C expression was 51.9¡¾30.1 and it was 72.9¡¾33.0 in the cases with 2+ expression for VEGF-C (p=0.07).
Conclusions: This study suggests that VEGF-C expression may have an association with lymph node metastasis in the patients with breast carcinoma.
Å°¿öµå
Breast Carcinoma;VEGF-C
¿ø¹® ¹× ¸µÅ©¾Æ¿ô Á¤º¸
µîÀçÀú³Î Á¤º¸