비소세포 폐암종에서 Thymidylate Synthase의 발현
Expression of Thymidylate Synthase in Non-Small Cell Lung Cancer
유진영, 김치홍, 조규도, 김훈교, 조덕곤, 안명임, 강석진, 김수지, 심병용, 김성환, 송소향,
소속 상세정보
유진영 ( Yoo Jin-Young )
가톨릭대학교 의과대학 임상병리학교실
김치홍 ( Kim Chi-Hong )
가톨릭대학교 의과대학 호흡기내과
조규도 ( Cho Kyu-Do )
가톨릭대학교 의과대학 흉부외과학교실
김훈교 ( Kim Hoon-Kyo )
가톨릭대학교 의과대학 종양내과
조덕곤 ( Cho Deog-Gon )
가톨릭대학교 의과대학 흉부외과학교실
안명임 ( Ahn Meyung-Im )
가톨릭대학교 의과대학 진단방사선과학교실
강석진 ( Kang Seok-Jin )
가톨릭대학교 의과대학 임상병리학교실
김수지 ( Kim Su-Zi )
가톨릭대학교 의과대학 종양방사선과학교실
심병용 ( Shim Byoung-Yong )
가톨릭대학교 의과대학 종양내과
김성환 ( Kim Sung-Hwan )
가톨릭대학교 의과대학 종양방사선과학교실
송소향 ( Song So-Hyang )
가톨릭대학교 의과대학 호흡기내과
KMID : 0357920050390060412
Abstract
Background: Thymidylate synthase (TS) catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), and this is an essential step in DNA biosynthesis. The present investigation was designed to determine the expression of TS in the patients with non-small cell lung cancer (NSCLC) and to assess the possible associations between the TS status and the p53 or proliferative index (PI).
Methods: The archival tumor tissues from 56 previously untreated NSCLC patients were examined by immunohistochemistry for TS, p53 and Ki-67.
Results: Forty-one men and 15 women (age range: 35 to 79 years, mean age: 62 years) were included in this study. The TS expression was high in 40 patients (71.4%) and low in 16 patients (28.6%). The aberrant expression of p53 was detected in 35 patients (62.5%). The mean PI for all the patients was 31.4±12.1. The TS-high tumors tended to be more poorly differentiated (p=0.069). The TS expression by a semiquantitative fourscale grading system was significantly correlated with the PIs (p=0.003). No correlation was established between the TS expression and the p53 status (p=0.806) or survival (p=0.951).
Conclusions: TS was not confirmed to be a useful marker for determining the prognosis of NSCLC patients. However, our data suggest that the tumor cells with higher TS expression have a higher proliferative activity.
키워드
Lung neoplasms;Thymidylate synthase;p53;Ki-67
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